Effects of extremely low-frequency electric fields at different intensities and exposure durations on mismatch negativity.
Kantar Gok D, Akpinar D, Yargicoglu P, Ozen S, Aslan M, Demir N, Derin N, Agar A. · 2014
View Original AbstractMMN amplitude was significantly decreased in the E18-4 group compared with the C4 group, and 4-HNE was increased in all experimental groups compared with the control group.
Plain English Summary
Researchers used ninety male rats, aged 3 months, to investigate how different intensities and durations of extremely low-frequency electric fields affected brain responses and oxidative damage. Rats were exposed to 12-kV/m and 18-kV/m electric fields for 2 or 4 weeks, and mismatch negativity (MMN) responses were recorded in anesthetized rats using electrodes placed on the dura. MMN amplitude was significantly decreased in the E18-4 group compared with the C4 group, and 4-HNE was increased in all experimental groups compared with the control group. The researchers concluded that the electric field decreased MMN amplitudes, possibly induced by lipid peroxidation.
Why This Matters
A total of six groups, composed of 15 animals each, included sham-exposed controls for 2 and 4 weeks and groups exposed to 12-kV/m and 18-kV/m electric fields for 2 or 4 weeks. MMN is a component of event-related potentials, and the researchers recorded these brain signals in urethane-anesthetized rats using electrodes positioned stereotaxically to the surface of the dura. After recordings, brain tissues were removed for 4-hydroxy-2-nonenal (4-HNE), protein carbonyl, and TUNEL analysis. Different change patterns in ERP parameters were observed dependent on the intensity and exposure duration of the electric fields. The significant decrease in MMN amplitude was found in the E18-4 group compared with the C4 group, while the increase in 4-HNE was seen across all experimental groups compared with the control group.
Exposure Details
- Electric Field
- 12000 and 18000 V/m
- Source/Device
- 50 Hz
- Exposure Duration
- 2 and 4 Weeks
Exposure Context
This study used 12000 and 18000 V/m for electric fields:
- 40Kx above the Building Biology guideline of 0.3 V/m
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Study Details
the purpose of the study was to investigate different intensities and exposure durations of ELF-EFs on MMN component of event-related potentials (ERPs) as well as apoptosis and oxidative brain damage in rats.
Ninety male rats, aged 3 months were used in our study. A total of six groups, composed of 15 animal...
In the current study, different change patterns in ERP parameters were observed dependent on the int...
Consequently, it could be concluded that electric field decreased MMN amplitudes possibly induced by lipid peroxidation.
Show BibTeX
@article{d_2014_effects_of_extremely_lowfrequency_265,
author = {Kantar Gok D and Akpinar D and Yargicoglu P and Ozen S and Aslan M and Demir N and Derin N and Agar A. },
title = {Effects of extremely low-frequency electric fields at different intensities and exposure durations on mismatch negativity.},
year = {2014},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0306452214003686},
}