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Reproductive Health

MnSOD expression inhibited by electromagnetic pulse radiation in the rat testis

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Zeng L, Ji X, Zhang Y, Miao X, Zou C, Lang H, Zhang J, Li Y, Wang X, Qi H, Ren D, Guo G · 2011

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Electromagnetic pulse exposure reduced antioxidant enzyme activity and raised hormone levels in male rat testes, with the damage possibly linked to inhibition of MnSOD expression.

Plain English Summary

Summary written for general audiences

Researchers exposed male Sprague Dawley rats to electromagnetic pulse irradiation at 100 kV/m peak-to-peak electric field intensity to observe effects on the reproductive system. Sperm morphology, micronucleus formation rate, sperm number, and viability were not affected, but the acrosin reaction rate decreased at 24 h and 48 h and recovered by 72 h after irradiation. Enzymatic activities of T-SOD and MnSOD were reduced by 24 h, MDA content increased at 6 h, and serum LH and testosterone levels were elevated in irradiated rats compared to controls. The researchers suggested that the mechanism of EMP-induced damage may be associated with inhibition of MnSOD expression.

Why This Matters

The study assessed multiple aspects of reproductive health, including sperm quality, testicular ultrastructure, hormone levels, and antioxidant enzyme activity. Testicular ultrastructure showed more serious damage at 24 h than at other time points examined, including 6 h, 12 h, and 48 h. Reductions in T-SOD and MnSOD enzyme activity were consistent with changes seen in MnSOD mRNA expression, suggesting effects at the gene expression level. Despite several measurable changes, basic sperm parameters such as morphology, number, and viability remained unaffected by irradiation.

Exposure Details

Electric Field
100000 V/m

Exposure Context

This study used 100000 V/m for electric fields:

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Study Details

To observe the effects of electromagnetic pulse exposure on the reproductive system in male rats.

Male Sprague Dawley rats were exposed to EMP irradiation of 100 kV/m peak-to-peak e-field intensity ...

EMP irradiation did not affect spermatozoon morphology, micronucleus formation rate, sperm number or...

Cite This Study
Zeng L, Ji X, Zhang Y, Miao X, Zou C, Lang H, Zhang J, Li Y, Wang X, Qi H, Ren D, Guo G (2011). MnSOD expression inhibited by electromagnetic pulse radiation in the rat testis Electromagn Biol Med. 30(4):205-218, 2011.
Show BibTeX
@article{l_2011_mnsod_expression_inhibited_by_487,
  author = {Zeng L and Ji X and Zhang Y and Miao X and Zou C and Lang H and Zhang J and Li Y and Wang X and Qi H and Ren D and Guo G},
  title = {MnSOD expression inhibited by electromagnetic pulse radiation in the rat testis},
  year = {2011},
  doi = {10.3109/15368378.2011.587929},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2011.587929},
}
DOI: 10.3109/15368378.2011.587929

Cited By (13 papers)

Quick Questions About This Study

EMP irradiation did not affect spermatozoon morphology, micronucleus formation rate, sperm number, or viability.
The acrosin reaction rate decreased at 24 h and 48 h after irradiation and recovered by 72 h compared to controls.
Serum levels of luteotrophic hormone and testosterone were elevated in irradiated rats compared to controls.
Enzymatic activities of T-SOD and MnSOD were reduced by 24 h, and MDA content increased at 6 h, consistent with changes in MnSOD mRNA expression.
The researchers suggested the mechanism of EMP-induced damage may be associated with the inhibition of MnSOD expression.