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Impact of 2.45 GHz microwave radiation on the testicular inflammatory pathway biomarkers in young rats: The role of gallic acid.

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Saygin M, Asci H, Ozmen O, Cankara FN, Dincoglu D, Ilhan I. · 2015

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Rats exposed to 2.45 GHz microwave radiation showed increased oxidative stress in the testes, while gallic acid supplementation lowered total oxidant status and oxidative stress index and raised total antioxidant status.

Plain English Summary

Summary written for general audiences

Six-week-old male Sprague Dawley rats were divided into four groups, including a sham group, an EMR-only group exposed to 2.45 GHz radiation for 3 hours per day for 30 days, an EMR plus gallic acid group, and a gallic acid-only group. EMR exposure increased malondialdehyde and total oxidant status levels, decreased total antioxidant status, and raised prostaglandin E2 and calcitonin gene-related peptide staining in testicular tubules. Gallic acid treatment lowered total oxidant status and oxidative stress index and raised total antioxidant status. It also reduced prostaglandin E2 and calcitonin gene-related peptide staining and increased testosterone and VEGF levels relative to the EMR-only group.

Why This Matters

In the EMR-only group, most seminiferous tubules contained fewer spermatozoa and spermatozoon counts decreased. The EMR plus gallic acid group showed increased mitotic activity in seminiferous tubule cells, indicating a regenerative reaction.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2.45 GHz Duration: 3 h day-1 for 30 days

Study Details

The aim of this study was to investigate electromagnetic radiation (EMR) transmitted by wireless devices (2.45 GHz), which may cause physiopathological or ultrastructural changes, in the testes of rats.

Six-week-old male Sprague Dawley rats were used in this study. Forty eight rats were equally divided...

Malondialdehyde (MDA) and total oxidant status (TOS) levels increased (p = 0.001 for both) in EMR on...

All these findings and the regenerative reaction, characterized by mitotic activity, increased in seminiferous tubules cells of the testes in EMR+GA group (p < 0.001). Long term EMR exposure resulted in testicular physiopathology via oxidative damage and inflammation. GA may have ameliorative effects on the prepubertal rat testes physiopathology.

Cite This Study
Saygin M, Asci H, Ozmen O, Cankara FN, Dincoglu D, Ilhan I. (2015). Impact of 2.45 GHz microwave radiation on the testicular inflammatory pathway biomarkers in young rats: The role of gallic acid. Environ Toxicol. 2015 Aug 13. doi: 10.1002/tox.22179.
Show BibTeX
@article{m_2015_impact_of_245_ghz_1703,
  author = {Saygin M and Asci H and Ozmen O and Cankara FN and Dincoglu D and Ilhan I.},
  title = {Impact of 2.45 GHz microwave radiation on the testicular inflammatory pathway biomarkers in young rats: The role of gallic acid.},
  year = {2015},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/26268881/},
}
PubMed: 26268881

Cited By (44 papers)

Quick Questions About This Study

Rats in the EMR-only group were exposed to 2.45 GHz microwave radiation for 3 hours per day over 30 days.
EMR exposure increased malondialdehyde and total oxidant status levels and decreased total antioxidant status.
Gallic acid reduced prostaglandin E2 and calcitonin gene-related peptide staining in testicular tubules.
Testosterone and VEGF levels rose in the EMR plus gallic acid group compared with the EMR-only group.
The authors concluded that long-term EMR exposure caused testicular physiopathology through oxidative damage and inflammation, and that gallic acid may ameliorate these effects.