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Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice

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Lameth J, Royer J, Martin A, Marie C, Arnaud-Cormos D, Lévêque P, Poirier R, Edeline JM, Mallat M · 2025

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5G-3.5 GHz exposure can induce molecular changes in brain gene expression without producing observable behavioral alterations in mice.

Plain English Summary

Summary written for general audiences

This study examined the effects of repeated head exposures to 5G signals at 3.5 GHz on adult male mice. The researchers found that while the 5G exposures did not alter behavioral outcomes, they did produce modifications in gene expression within the cerebral cortex.

Why This Matters

This finding suggests potential subclinical biological effects of radiofrequency exposure that may not manifest as overt behavioral changes. Further investigation would be needed to determine the functional significance and long-term implications of altered cortical gene expression in this context.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Lameth J, Royer J, Martin A, Marie C, Arnaud-Cormos D, Lévêque P, Poirier R, Edeline JM, Mallat M (2025). Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice.
Show BibTeX
@article{lameth_j_royer_j_martin_a_marie_c_arnaud_cormos_d_lvque_p_poirier_r_edeline_jm_mallat_m_ce3927,
  author = {Lameth J and Royer J and Martin A and Marie C and Arnaud-Cormos D and Lévêque P and Poirier R and Edeline JM and Mallat M},
  title = {Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice},
  year = {2025},
  doi = {10.1080/15368378.2025.2577318},
  
}
DOI: 10.1080/15368378.2025.2577318

Quick Questions About This Study

Yes, this study found significant thyroid damage persisting one year after birth in rats whose mothers were exposed to 2.45 GHz radiation during pregnancy, suggesting these effects may be permanent rather than temporary developmental disruptions.
Prenatal 2.45 GHz exposure caused increased tissue scarring, abnormal thyroid cells, degenerated follicles, reduced colloid, increased cell death, and DNA double-strand breaks that were still present one year after birth.
Yes, the 12 mW/kg whole-body SAR used in this study is well within current safety limits and comparable to exposure levels from WiFi routers, smartphones, and other 2.45 GHz devices in typical daily use.
No, this study found thyroid damage persisted one year after birth even though offspring were not exposed to radiation after birth, suggesting prenatal EMF effects may cause lasting thyroid problems throughout life.
Yes, mothers exposed to 2.45 GHz radiation 24 hours daily throughout pregnancy produced offspring with significant thyroid cellular damage, DNA breaks, and tissue scarring that persisted into adulthood, indicating developmental programming effects.