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Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice

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Authors not listed · 2025

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Repeated head exposures to a 5G-3.5 GHz signal can trigger mild transcriptome alterations without changing memory or emotional state in mice.

Plain English Summary

Summary written for general audiences

Researchers exposed mice to a 5G-modulated 3.5 GHz signal for 1 hour daily, 5 days per week over six weeks at a brain-averaged SAR of 0.19 W/kg. Behavioral tests after four weeks showed no significant effects on locomotion, anxiety, or memory. mRNA profiling at the end revealed significant expression changes in less than 1% of genes, with over-representation of glutamatergic synapse genes. The right cortical area with a SAR of 0.43 W/kg showed more mitochondrial genome-encoded responsive genes than the left area with a SAR of 0.14 W/kg.

Why This Matters

The authors note that 5G networks increase human exposure to 3.5 GHz electromagnetic fields. They conclude that repeated head exposures can trigger mild transcriptome alterations without affecting memory or emotional state.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 3.5 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 3.5 GHzPower lines50/60 HzCell phones~1 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2025). Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice.
Show BibTeX
@article{repeated_head_exposures_to_a_5g_35_ghz_signal_do_not_alter_behavior_but_modify_intracortical_gene_expression_in_adult_male_mice_ce2891,
  author = {Unknown},
  title = {Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice},
  year = {2025},
  doi = {10.3390/ijms26062459},
  
}

Quick Questions About This Study

Mice were exposed to a 5G-modulated 3.5 GHz signal for 1 hour daily, 5 days per week over six weeks at a brain-averaged SAR of 0.19 W/kg.
Behavioral tests after four weeks showed no significant effects on locomotion, anxiety, or memory.
mRNA profiling revealed significant expression changes in less than 1% of genes, with over-representation of glutamatergic synapse genes.
The right cortical area with a SAR of 0.43 W/kg showed more mitochondrial genome-encoded responsive genes than the left area with a SAR of 0.14 W/kg.
Repeated head exposures to a 5G-3.5 GHz signal can trigger mild transcriptome alterations without changes in memory capacities or emotional state.