Long-lasting anti-tremor induced by 2-Br-alpha-ergocryptine in monkeys
Miyamoto T, Battista A, Goldstein M, Fuxe M · 1974
Repeated CB 154 administration eliminated tremor for at least 48 hours and reduced tremor intensity for another 24-48 hours after stopping.
Plain English Summary
Researchers gave CB 154 to five green monkeys with brainstem lesions that caused tremor. A single dose of CB 154 stopped tremor for about one hour. Repeated dosing stopped tremor for at least 48 hours, with reduced tremor lasting another 24-48 hours after treatment ended. Repeated CB 154 also caused moderate involuntary movements that lasted less long than the tremor relief. CB 154 reduced hypokinesia in three of the five monkeys.
Why This Matters
In monkey IV, a single CB 154 dose caused involuntary movements lasting 24 hours. The researchers noted that CB 154's anti-tremor effect could last 4-5 days while involuntary movements lasted no more than a day.
Finding
Repeated administration of CB 154 (5-8 mg kg he. ip.) resulted in the disappearance of the tremor for at least 48 h: After cessation of treatment the intensity of the tremor was diminished for another 24-48 h. The long-lasting anti-tremor effect of the drug was further illustrated when CB 154 treatment was interrupted: on the third day in monkey No. I (Table 1). At this time (day 7) the administration of CB 154 resulted in a much longer lasting disappearance of the tremor (approx. 10 h) as compared with the single administration of the drug on the first day of treatment (approx. 1 h).
In their words
“Repeated administration of CB 154 (5-8 mg kg he. ip.) resulted in the disappearance of the tremor for at least 48 h: After cessation of treatment the intensity of the tremor was diminished for another 24-48 h. The long-lasting anti-tremor effect of the drug was further illustrated when CB 154 treatment was interrupted: on the third day in monkey No. I (Table 1). At this time (day 7) the administration of CB 154 resulted in a much longer lasting disappearance of the tremor (approx. 10 h) as compared with the single administration of the drug on the first day of treatment (approx. 1 h).”
Show BibTeX
@article{long_lasting_anti_tremor_induced_by_2_br_alpha_ergocryptine_in_monkeys_g7081,
author = {Miyamoto T and Battista A and Goldstein M and Fuxe M},
title = {Long-lasting anti-tremor induced by 2-Br-alpha-ergocryptine in monkeys},
year = {1974},
}