Long-lasting anti-tremor induced by 2-Br-alpha-ergocryptine in monkeys
Miyamoto T, Battista A, Goldstein M, Fuxe M · 1974
1974 monkey study showed dopamine-stimulating drugs could provide long-lasting tremor relief, highlighting neurological pathways now known to be EMF-sensitive.
Plain English Summary
This 1974 study examined whether a dopamine-stimulating drug called 2-Br-α-ergocryptine (CB 154) could provide long-lasting relief from surgically-induced tremor in monkeys. Researchers found that repeated administration of this ergot alkaloid successfully reduced tremor symptoms for extended periods in monkeys with specific brain lesions.
Why This Matters
While this study appears to focus on pharmaceutical interventions for movement disorders rather than EMF exposure, it's worth noting that this research occurred during the early era of EMF health investigations when researchers were exploring various mechanisms of neurological disruption. The study's focus on dopamine receptor stimulation is particularly relevant because modern research shows that EMF exposure can disrupt dopamine signaling pathways in the brain. What's concerning is how little we understood about electromagnetic influences on neurological function in 1974, yet we were already introducing powerful wireless technologies into daily life. The reality is that dopamine systems affected by pharmaceutical agents in this monkey study are the same systems that current research suggests may be vulnerable to chronic EMF exposure from our wireless devices.
Finding
Repeated administration of CB 154 (5-8 mg kg he. ip.) resulted in the disappearance of the tremor for at least 48 h: After cessation of treatment the intensity of the tremor was diminished for another 24-48 h. The long-lasting anti-tremor effect of the drug was further illustrated when CB 154 treatment was interrupted: on the third day in monkey No. I (Table 1). At this time (day 7) the administration of CB 154 resulted in a much longer lasting disappearance of the tremor (approx. 10 h) as compared with the single administration of the drug on the first day of treatment (approx. 1 h).
In their words
“Repeated administration of CB 154 (5-8 mg kg he. ip.) resulted in the disappearance of the tremor for at least 48 h: After cessation of treatment the intensity of the tremor was diminished for another 24-48 h. The long-lasting anti-tremor effect of the drug was further illustrated when CB 154 treatment was interrupted: on the third day in monkey No. I (Table 1). At this time (day 7) the administration of CB 154 resulted in a much longer lasting disappearance of the tremor (approx. 10 h) as compared with the single administration of the drug on the first day of treatment (approx. 1 h).”
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{long_lasting_anti_tremor_induced_by_2_br_alpha_ergocryptine_in_monkeys_g7081,
author = {Miyamoto T and Battista A and Goldstein M and Fuxe M},
title = {Long-lasting anti-tremor induced by 2-Br-alpha-ergocryptine in monkeys},
year = {1974},
}