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Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

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Bouji M, Lecomte A, Hode Y, de Seze R, Villégier AS · 2012

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GSM exposure at 900 MHz raised IL-1β in the olfactory bulb and enhanced emotional memory in middle-aged rats, while raising corticosterone only in young adult rats.

Plain English Summary

Summary written for general audiences

Researchers assessed the effects of a single GSM exposure at 900 MHz with a specific absorption rate of 6 W/kg on young adult (6-week-old) and middle-aged (12-month-old) rats. The study measured brain IL-1β and IL-6, plasmatic corticosterone levels, and emotional memory. Results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, while plasmatic corticosterone levels increased in GSM-exposed young adults. Acute GSM exposure did not induce astrocyte activation, in contrast to previously published work.

Why This Matters

The researchers studied the reactivity of middle-aged brains to EMF exposure, noting that the transition from middle-age to senescence is highly dependent on environment and lifestyle. The overall pattern the researchers described was an age dependency of reactivity to GSM exposure across neuro-immunity, stress, and behavioral parameters. The researchers suggested that reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.

Exposure Details

SAR
6 W/kg
Source/Device
900 MHz
Exposure Duration
15 min

Exposure Context

This study used 6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 6 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 4 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To assess the effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Since the transition from middle-age to senescence is highly dependent on environment and lifestyle,...

Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce...

Altogether, our data showed an age dependency of reactivity to GSM exposure in neuro-immunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters

Cite This Study
Bouji M, Lecomte A, Hode Y, de Seze R, Villégier AS (2012). Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats Exp Gerontol. 47(6):444-451, 2012.
Show BibTeX
@article{m_2012_effects_of_900_mhz_72,
  author = {Bouji M and Lecomte A and Hode Y and de Seze R and Villégier AS},
  title = {Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats},
  year = {2012},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0531556512000708},
}

Quick Questions About This Study

The study used young adult rats aged 6 weeks and middle-aged rats aged 12 months.
Rats received a single 15 min GSM exposure at 900 MHz with a specific absorption rate of 6 W/kg.
Acute GSM exposure did not induce astrocyte activation, which contrasted with previously published work.
Middle-aged rats showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory, while young adults showed increased plasmatic corticosterone levels. The researchers described this pattern as an age dependency of reactivity to GSM exposure.
The researchers noted that the transition from middle-age to senescence is highly dependent on environment and lifestyle, and studied the reactivity of middle-aged brains to EMF exposure.