Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.
Nazıroğlu M, Çelik Ö, Özgül C, Çiğ B, Doğan S, Bal R, Gümral N, Rodríguez AB, Pariente JA · 2012
View Original AbstractWiFi-frequency radiation damaged rat brain cells and disrupted brain waves, but melatonin supplementation significantly reduced the harm.
Plain English Summary
Researchers exposed rats to 2.45 GHz wireless radiation (the same frequency used by WiFi and microwave ovens) for one hour daily over 30 days, finding it caused brain damage including increased calcium influx into neurons, oxidative stress, and abnormal brain wave activity. When rats were given melatonin supplements along with the radiation exposure, these harmful effects were significantly reduced, suggesting melatonin may protect against wireless radiation damage to the nervous system.
Why This Matters
This study adds to mounting evidence that wireless radiation at 2.45 GHz can cause measurable biological harm to the nervous system, even from relatively brief daily exposures. The frequency tested is identical to what your WiFi router, microwave oven, and many wireless devices emit. What makes this research particularly significant is that it demonstrates a clear biological mechanism for the damage: disrupted calcium channels in brain cells, which can trigger a cascade of cellular dysfunction. The protective effect of melatonin is encouraging and aligns with other research showing antioxidants can help mitigate EMF damage. However, the key takeaway isn't that supplements are the answer, but rather that the radiation itself is causing oxidative stress and neurological changes that your body has to work to counteract. This study reinforces why reducing your exposure to wireless radiation, especially in sleeping areas where your body naturally produces melatonin for repair, is a prudent health strategy.
Exposure Information
Specific exposure levels were not quantified in this study. The study examined exposure from: 2.45 GHz Duration: 60 min/day for 30 days
Study Details
We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca(2+) influx, cell viability and electroencephalography (EEG) records in the rat.
Thirty two rats were equally divided into four different groups namely group A1: Cage control, group...
Lipid peroxidation (LP), cell viability and cytosolic Ca(2+) values in DRG neurons were higher in gr...
In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca(2+) influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca(2+) channels.
Show BibTeX
@article{m_2012_melatonin_modulates_wireless_245_2466,
author = {Nazıroğlu M and Çelik Ö and Özgül C and Çiğ B and Doğan S and Bal R and Gümral N and Rodríguez AB and Pariente JA},
title = {Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.},
year = {2012},
url = {https://pubmed.ncbi.nlm.nih.gov/22019785/},
}