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Brain & Nervous System

Epilepsy but not mobile phone frequency (900 MHz) induces apoptosis and calcium entry in hippocampus of epileptic rat: involvement of TRPV1 channels.

No Effects Found

Nazıroğlu M, Özkan FF, Hapil SR, Ghazizadeh V, Çiğ B. · 2015

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Cell phone radiation didn't worsen brain cell damage in epileptic rats, suggesting EMF may not amplify existing neurological conditions.

Plain English Summary

Summary written for general audiences

Researchers exposed brain cells from epileptic rats to 900 MHz cell phone radiation for one hour to see if it would worsen brain damage. While epilepsy itself caused significant cellular damage including cell death and calcium influx, the cell phone radiation did not add any additional harmful effects. This suggests that 900 MHz EMF exposure may not exacerbate existing brain conditions like epilepsy.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 900 MHz Duration: 1 h

Study Details

We investigated the effects of mobile phone (900 MHz) EMR exposure on Ca2+ influx, apoptosis, oxidative stress, and TRPV1 channel activations in the hippocampus of pentylenetetrazol (PTZ)-induced epileptic rats.

Freshly isolated hippocampal neurons of twenty-one rats were used in study within three groups namel...

The apoptosis, mitochondrial membrane depolarization, intracellular reactive oxygen species (ROS), a...

In conclusion, apoptosis, mitochondrial, ROS, and Ca2+ influx via TRPV1 channel were increased in the hippocampal neurons by epilepsy induction although the mobile phone did not change the values. The results indicated that TRPV1 channels in hippocampus may possibly be a novel target for effective target of epilepsy.

Cite This Study
Nazıroğlu M, Özkan FF, Hapil SR, Ghazizadeh V, Çiğ B. (2015). Epilepsy but not mobile phone frequency (900 MHz) induces apoptosis and calcium entry in hippocampus of epileptic rat: involvement of TRPV1 channels. J Membr Biol. 248(1):83-91, 2015.
Show BibTeX
@article{m_2015_epilepsy_but_not_mobile_2886,
  author = {Nazıroğlu M and Özkan FF and Hapil SR and Ghazizadeh V and Çiğ B.},
  title = {Epilepsy but not mobile phone frequency (900 MHz) induces apoptosis and calcium entry in hippocampus of epileptic rat: involvement of TRPV1 channels.},
  year = {2015},
  doi = {10.1007/s00232-014-9744-y},
  url = {https://link.springer.com/article/10.1007/s00232-014-9744-y},
}
DOI: 10.1007/s00232-014-9744-y

Cited By (19 papers)

Quick Questions About This Study

No, 900 MHz cell phone radiation does not make epilepsy worse in brain cells. A 2015 study exposed epileptic rat brain cells to one hour of 900 MHz radiation and found no additional cellular damage beyond what epilepsy itself caused.
Cell phone radiation alone does not trigger calcium influx in hippocampal neurons. The 2015 Nazıroğlu study found that while epilepsy increased calcium concentrations through TRPV1 channels, 900 MHz EMF exposure added no additional calcium changes in brain cells.
One hour of 900 MHz exposure does not cause additional brain cell death in epileptic conditions. Research on epileptic rat neurons showed that while epilepsy itself increased apoptosis and cellular damage, cell phone radiation produced no extra harmful effects.
900 MHz radiation does not significantly affect TRPV1 channels in epileptic brain tissue. The 2015 study found that epilepsy increased calcium influx through these channels, but cell phone radiation did not alter TRPV1 channel activity or calcium concentrations.
Mobile phone frequencies do not worsen mitochondrial damage in epileptic hippocampus. Research found that epilepsy caused mitochondrial membrane depolarization and increased reactive oxygen species, but 900 MHz EMF exposure added no additional mitochondrial dysfunction to brain cells.