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Effect of Environmental Extremely Low-Frequency Electromagnetic Fields Exposure on Inflammatory Mediators and Serotonin Metabolism in a Human Neuroblastoma Cell Line.

No Effects Found

Reale M, D'Angelo C, Costantini E, Tata AM, Regen F, Hellmann-Regen J. · 2016

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Brain cells showed no significant damage from 48-hour exposure to power line frequency EMFs at levels higher than typical household exposure.

Plain English Summary

Summary written for general audiences

Researchers exposed human brain cells to extremely low frequency electromagnetic fields (the type from power lines) for up to 48 hours to see if it would cause neurological damage. They found no significant harmful effects on the cells' ability to manage oxidative stress or inflammation, though there were minor changes in serotonin metabolism. The study suggests that ELF-EMF exposure at these levels is unlikely to contribute to neurodegenerative diseases.

Study Details

Due to lack of a direct link between neurodegenerative processes and ELF-EMF exposure, our goal was to investigate if ELF-EMF exposure may represent a possible risk factor.

In the present study, using neuronal-like SH-SY5Y neuroblastoma cells, we show that the balance betw...

In SH-SY5Y-exposed cells we observed increased intracellular 5-hydroxyindoleacetic acid/5-hydroxytry...

These results are in accord with epidemiological studies that have provided little support for a link between ELF-EMFs and neurodegeneration.

Cite This Study
Reale M, D'Angelo C, Costantini E, Tata AM, Regen F, Hellmann-Regen J. (2016). Effect of Environmental Extremely Low-Frequency Electromagnetic Fields Exposure on Inflammatory Mediators and Serotonin Metabolism in a Human Neuroblastoma Cell Line. CNS Neurol Disord Drug Targets. 15(10):1203-1215, 2016.
Show BibTeX
@article{m_2016_effect_of_environmental_extremely_2903,
  author = {Reale M and D'Angelo C and Costantini E and Tata AM and Regen F and Hellmann-Regen J.},
  title = {Effect of Environmental Extremely Low-Frequency Electromagnetic Fields Exposure on Inflammatory Mediators and Serotonin Metabolism in a Human Neuroblastoma Cell Line.},
  year = {2016},
  
  url = {https://www.ingentaconnect.com/content/ben/cnsnddt/2016/00000015/00000010/art00003},
}

Quick Questions About This Study

Researchers exposed human brain cells to extremely low frequency electromagnetic fields (the type from power lines) for up to 48 hours to see if it would cause neurological damage. They found no significant harmful effects on the cells' ability to manage oxidative stress or inflammation, though there were minor changes in serotonin metabolism. The study suggests that ELF-EMF exposure at these levels is unlikely to contribute to neurodegenerative diseases.