8,700 Studies Reviewed. 87.0% Found Biological Effects. The Evidence is Clear.

Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.

No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines

No Effects Found

Villarini M, Gambelunghe A, Giustarini D, Ambrosini MV, Fatigoni C, Rossi R, Dominici L, Levorato S, Muzi G, Piobbico D, Mariucci G · 2017

View Original Abstract
Share:

Brain cancer cells showed no DNA damage from power-frequency magnetic fields up to 1 mT, even when combined with aluminum.

Plain English Summary

Summary written for general audiences

Italian researchers exposed brain cancer cells (neuroblastoma) to 50 Hz magnetic fields and aluminum compounds, both separately and together, to see if they would cause DNA damage. After exposing the cells to magnetic field levels ranging from 0.01 to 1 mT for up to 5 hours, they found no DNA damage, no changes in cellular stress markers, or any harmful synergistic effects when the exposures were combined. This suggests that short-term exposure to these power-frequency magnetic fields, even in combination with aluminum, does not appear to damage DNA in these particular brain cell types.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

The study examined exposure from: 50 Hz Duration: 1 hour or 5 hour

Study Details

To investigate the effects of co-exposure to a 50 Hz magnetic field and aluminium on DNA damage in neuroblastoma cell lines.

SH-SY5Y5 and SK-N-BE-2 cells underwent exposure to 50 Hz ELF-MF (0.01, 0.1 or 1 mT) or AlCl3 (4 or 4...

Neither exposure to ELF-MF or AlCl3 alone induced DNA damage, changes in GSH/GSSG ratio or variation...

The results of this in vitro study, which deals with the effects of co-exposure to 50 Hz MF and Aluminum, seem to exclude that short-term exposure to ELF-MF in combination with Al can have harmful effects on human SH-SY5Y and SK-N-BE-2 cells.

Cite This Study
Villarini M, Gambelunghe A, Giustarini D, Ambrosini MV, Fatigoni C, Rossi R, Dominici L, Levorato S, Muzi G, Piobbico D, Mariucci G (2017). No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines Mutat Res. 823:11-21, 2017.
Show BibTeX
@article{m_2017_no_evidence_of_dna_2861,
  author = {Villarini M and Gambelunghe A and Giustarini D and Ambrosini MV and Fatigoni C and Rossi R and Dominici L and Levorato S and Muzi G and Piobbico D and Mariucci G},
  title = {No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines},
  year = {2017},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S1383571817300852},
}

Quick Questions About This Study

No, a 2017 Italian study found that 50 Hz magnetic fields combined with aluminum compounds caused no DNA damage in neuroblastoma brain cancer cells. Researchers tested exposures up to 1 mT for 5 hours and found no harmful synergistic effects between the two substances.
No, research on neuroblastoma brain cancer cells showed that 50 Hz magnetic field exposure (0.01 to 1 mT) for up to 5 hours caused no DNA damage. The study also found no changes in cellular stress markers or protective protein expression.
No, combining aluminum chloride with 50 Hz magnetic fields did not increase DNA damage in brain cancer cells. Italian researchers specifically tested whether aluminum compounds would make power frequency EMF more harmful, but found no synergistic toxic effects in their 2017 study.
According to 2017 research on neuroblastoma cells, exposure to 50 Hz magnetic fields up to 1 mT for 5 hours caused no DNA damage or cellular stress. However, this was an in vitro study on cancer cells, not normal brain tissue.
No, 50 Hz magnetic field exposure did not change Hsp70 stress protein expression in neuroblastoma brain cancer cells. The 2017 study also found no alterations in cellular antioxidant levels (GSH/GSSG ratio) after magnetic field exposure up to 1 mT.