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No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines

No Effects Found

Villarini M, Gambelunghe A, Giustarini D, Ambrosini MV, Fatigoni C, Rossi R, Dominici L, Levorato S, Muzi G, Piobbico D, Mariucci G · 2017

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Brain cancer cells showed no DNA damage from power-frequency magnetic fields up to 1 mT, even when combined with aluminum.

Plain English Summary

Summary written for general audiences

Italian researchers exposed brain cancer cells (neuroblastoma) to 50 Hz magnetic fields and aluminum compounds, both separately and together, to see if they would cause DNA damage. After exposing the cells to magnetic field levels ranging from 0.01 to 1 mT for up to 5 hours, they found no DNA damage, no changes in cellular stress markers, or any harmful synergistic effects when the exposures were combined. This suggests that short-term exposure to these power-frequency magnetic fields, even in combination with aluminum, does not appear to damage DNA in these particular brain cell types.

Study Details

To investigate the effects of co-exposure to a 50 Hz magnetic field and aluminium on DNA damage in neuroblastoma cell lines.

SH-SY5Y5 and SK-N-BE-2 cells underwent exposure to 50 Hz ELF-MF (0.01, 0.1 or 1 mT) or AlCl3 (4 or 4...

Neither exposure to ELF-MF or AlCl3 alone induced DNA damage, changes in GSH/GSSG ratio or variation...

The results of this in vitro study, which deals with the effects of co-exposure to 50 Hz MF and Aluminum, seem to exclude that short-term exposure to ELF-MF in combination with Al can have harmful effects on human SH-SY5Y and SK-N-BE-2 cells.

Cite This Study
Villarini M, Gambelunghe A, Giustarini D, Ambrosini MV, Fatigoni C, Rossi R, Dominici L, Levorato S, Muzi G, Piobbico D, Mariucci G (2017). No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines Mutat Res. 823:11-21, 2017.
Show BibTeX
@article{m_2017_no_evidence_of_dna_2861,
  author = {Villarini M and Gambelunghe A and Giustarini D and Ambrosini MV and Fatigoni C and Rossi R and Dominici L and Levorato S and Muzi G and Piobbico D and Mariucci G},
  title = {No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines},
  year = {2017},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S1383571817300852},
}

Quick Questions About This Study

Italian researchers exposed brain cancer cells (neuroblastoma) to 50 Hz magnetic fields and aluminum compounds, both separately and together, to see if they would cause DNA damage. After exposing the cells to magnetic field levels ranging from 0.01 to 1 mT for up to 5 hours, they found no DNA damage, no changes in cellular stress markers, or any harmful synergistic effects when the exposures were combined. This suggests that short-term exposure to these power-frequency magnetic fields, even in combination with aluminum, does not appear to damage DNA in these particular brain cell types.