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Oxidative Stress

Effects of 2.45 GHz microwave exposures on the peroxidation status in Wistar rats

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Aweda MA, Gbenebitse S, Meidinyo RO · 2003

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Exposure to 2.45 GHz microwaves caused a significant increase in lipid peroxidation in Wistar rats, while antioxidants ascorbic acid and alpha-tocopherol reduced that increase.

Plain English Summary

Summary written for general audiences

Researchers studied the effects of 2.45 GHz microwave exposure on the lipid peroxidation status of 120 Wistar rats at a power density of 6 mWcm(-2). Lipid peroxidation status in the rats was monitored for 8 weeks after irradiation using the thiobarbituric acid method. Microwave exposure raised the lipid peroxidation status from a mean control value of 4.18 x 10(-6)g 1(-1) to a maximum of 6.50 x 10(-6) g 1(-1) within the first 24 hours, after which it gradually returned toward the control value. The results demonstrated that microwave exposures cause a significant increase in lipid peroxidation status and that ascorbic acid and alpha-tocopherol had protective effects.

Why This Matters

Lipid peroxidation is the process measured here via the thiobarbituric acid method, referred to throughout as lipid peroxidation status or LPS. When ascorbic acid was given before irradiation, the lipid peroxidation status fell from the control value to a minimum of 2.86 x 10(-6)g 1(-1) within the first week, then gradually rose to a maximum of 3.96 x 10(-6)g 1(-1) during the monitoring period. When alpha-tocopherol was given before irradiation, the lipid peroxidation status fell to a minimum of 2.10 x 10(-6) g 1(-1) within the first week, then gradually rose to a maximum of 3.94 x 10(-6)g 1(-1) during the monitoring period.

Exposure Details

Power Density
6 mW/cm²
Source/Device
2.45 GHz
Exposure Duration
8 weeks

Exposure Context

This study used 6 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 6 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)This level is 6 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study is to observe the Effects of 2.45 GHz microwave exposures on the peroxidation status in Wistar rats.

The effects on the lipid peroxidation status (LPS) of whole body irradiation of 120 Wistar rats with...

The MW exposures caused an increase in the LPS from the mean control value of 4.18 x 10(-6)g 1(-1)to...

The results obtained from this study demonstrate that MW exposures cause significant increase in the LPS and there are protective effects of the anti-oxidants ascorbic acid and alpha-tocopherol.

Cite This Study
Aweda MA, Gbenebitse S, Meidinyo RO (2003). Effects of 2.45 GHz microwave exposures on the peroxidation status in Wistar rats Niger Postgrad Med J. 10(4):243-246, 2003.
Show BibTeX
@article{ma_2003_effects_of_245_ghz_511,
  author = {Aweda MA and Gbenebitse S and Meidinyo RO},
  title = {Effects of 2.45 GHz microwave exposures on the peroxidation status in Wistar rats},
  year = {2003},
  
  url = {https://europepmc.org/article/med/15045019},
}
PubMed: 15045019

Cited By (24 papers)

Quick Questions About This Study

The study used 120 Wistar rats exposed to whole-body microwave irradiation.
Microwave exposures caused a significant increase in lipid peroxidation status, rising from 4.18 x 10(-6)g 1(-1) to a maximum of 6.50 x 10(-6) g 1(-1) within the first 24 hours.
Both ascorbic acid and alpha-tocopherol, each administered before irradiation, caused a decrease in lipid peroxidation status from the control value.
Lipid peroxidation status was monitored for a period of 8 weeks after irradiation.
The rats were exposed to 2.45 GHz microwaves at a power density of 6 mWcm(-2).