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The effect of mobile phone on the number of Purkinje cells: a stereological study

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Rağbetli MC, Aydinlioğlu A, Koyun N, Rağbetli C, Bektas S, Ozdemir S · 2010

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Exposure to mobile phone radiation was associated with a significant decrease in Purkinje cell numbers in the developing mouse cerebellum.

Plain English Summary

Summary written for general audiences

Researchers investigated the effect of mobile phone exposure on Purkinje and granule neurons in the developing cerebellum. Pregnant Swiss albino mice were exposed to GSM mobile phone radiation at 890–915 MHz at 0.95 W/Kg specific absorption rate (SAR). The study found a significant decrease in the number of Purkinje cells and a tendency for granule cells to increase.

Why This Matters

The study used male and female Swiss albino mice divided into control and mobile phone-exposed groups. Cerebellar tissue sections were stained with Haematoxylin-eosin and cresyl violet for analysis. Cell counting was carried out using the optical fractionator method, with cerebellar areas analysed by Axiovision software. The researchers noted that further studies are needed given the popular use of mobile telephones and relatively high exposure on the developing brain.

Exposure Details

SAR
0.95 W/kg
Source/Device
890–915 MHz Mobile Phone

Exposure Context

This study used 0.95 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.95 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 915 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 915 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The present study investigated the effect of exposure to mobile phone on the number of Purkinje and granule neurons in the developing cerebellum.

Male and female Swiss albino mice were housed as control and mobile phone-exposed groups. Pregnant a...

A significant decrease in the number of Purkinje cells and a tendency for granule cells to increase ...

Further studies in this area are needed due to the popular use of mobile telephones and relatively high exposure on developing brain.

Cite This Study
Rağbetli MC, Aydinlioğlu A, Koyun N, Rağbetli C, Bektas S, Ozdemir S (2010). The effect of mobile phone on the number of Purkinje cells: a stereological study Int J Radiat Biol. 86(7):548-554, 2010.
Show BibTeX
@article{mc_2010_the_effect_of_mobile_172,
  author = {Rağbetli MC and Aydinlioğlu A and Koyun N and Rağbetli C and Bektas S and Ozdemir S},
  title = {The effect of mobile phone on the number of Purkinje cells: a stereological study},
  year = {2010},
  doi = {10.3109/09553001003734527},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553001003734527},
}
DOI: 10.3109/09553001003734527

Cited By (33 papers)

Quick Questions About This Study

The study used male and female Swiss albino mice housed as control and mobile phone-exposed groups.
Pregnant mice were exposed to GSM mobile phone radiation at 890–915 MHz at 0.95 W/Kg SAR.
A significant decrease in the number of Purkinje cells was found in the cerebellum.
There was a tendency for granule cells to increase in the cerebellum of exposed animals.
Cell counting was performed using the optical fractionator method, with optical dissectors systematically spaced at random and focused to the widest profile of the neuron cell nucleus.