Microwave radiation induces neuronal autophagy through miR-30a-5p/AMPKα2 signal pathway
Authors not listed · 2022
Exposing rat hippocampal neurons and PC12 neuron-like cells to 30 mW/cm2 microwaves down-regulated miR-30a and activated autophagy, and the authors concluded that microwave radiation promotes neuronal autophagy through the miR-30a/AMPKα2 pathway.
Plain English Summary
Researchers exposed rat hippocampal neurons and PC12-derived neuron-like cells to 30 mW/cm2 microwaves, which down-regulated miR-30a and activated autophagy in vivo and in vitro. Bioinformatics analysis identified several potential miR-30a targets, and the team selected Prkaa2 for further study because prior work linked microwave radiation to abnormal energy metabolism in neurons. Dual-luciferase assays confirmed Prkaa2 as a downstream gene of miR-30a, and microwave exposure increased AMPKα2 expression and AMPKα Thr172 phosphorylation, while miR-30a mimics reversed these changes and blocked autophagy.
Why This Matters
When miR-30a was overexpressed in PC12 cells, it abolished the autophagy triggered by microwave exposure and prevented the radiation-induced rise in AMPKα2 and its phosphorylation. The authors noted that their earlier work had shown 2856 MHz microwave radiation damaged synaptic plasticity and activated autophagy in neurons.
Show BibTeX
@article{microwave_radiation_induces_neuronal_autophagy_through_mir_30a_5pampk2_signal_pathway_ce2814,
author = {Unknown},
title = {Microwave radiation induces neuronal autophagy through miR-30a-5p/AMPKα2 signal pathway},
year = {2022},
}