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Changes in serum alkaline phosphatase activity during in vitro exposure to amplitude-modulated electromagnetic field of ultrahigh frequency (2375 MHz) in guinea pigs

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Pashovkina MS, Akoev IG · 2000

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Microwave radiation at WiFi-like frequencies doubled cellular enzyme activity in minutes, suggesting biological responses occur faster than previously thought.

Plain English Summary

Summary written for general audiences

Russian researchers exposed guinea pig blood samples to 2375 MHz microwave radiation (similar to WiFi frequencies) for just 1-3 minutes and measured changes in alkaline phosphatase, an important enzyme involved in cellular metabolism. They found that specific pulse frequencies, particularly at 70 Hz, nearly doubled the enzyme's activity levels. This suggests that even brief exposures to common wireless frequencies can trigger measurable biological responses at the cellular level.

Why This Matters

This study adds to the growing body of evidence that EMF exposure creates biological effects even at very low power levels and short durations. The 2375 MHz frequency used here sits squarely in the range of common wireless technologies we use daily. What makes this research particularly significant is that the researchers found the biological response wasn't just about the radiation intensity, but also about how it was pulsed - with 70 Hz modulation creating the strongest effect. This frequency-specific response suggests our cells are responding to the information patterns in EMF signals, not just their raw power. The doubling of enzyme activity in just minutes of exposure raises important questions about what happens with the hours of daily exposure most of us experience from our wireless devices.

Exposure Details

SAR
8 W/kg
Power Density
0.0008 µW/m²
Source/Device
2375 MHz
Exposure Duration
1 and 3 min

Exposure Context

This study used 0.0008 µW/m² for radio frequency:

This study used 8 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.0008 µW/m²Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 12,500,000,000x higher than this exposure level

Study Details

The activity of alkaline phosphatase by the action of pulse-modulated microwave radiation was studied.

The carrier frequency of radiation was 2375 MHz, the range of modulation pulse rate was 10-390 Hz wi...

It was shown that the activity of alkaline phosphatase depends on both modulation frequency and inte...

Cite This Study
Pashovkina MS, Akoev IG (2000). Changes in serum alkaline phosphatase activity during in vitro exposure to amplitude-modulated electromagnetic field of ultrahigh frequency (2375 MHz) in guinea pigs Biofizika 45(1):130-136, 2000.
Show BibTeX
@article{ms_2000_changes_in_serum_alkaline_1254,
  author = {Pashovkina MS and Akoev IG},
  title = {Changes in serum alkaline phosphatase activity during in vitro exposure to amplitude-modulated electromagnetic field of ultrahigh frequency (2375 MHz) in guinea pigs},
  year = {2000},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/10732222/},
}

Quick Questions About This Study

Russian researchers exposed guinea pig blood samples to 2375 MHz microwave radiation (similar to WiFi frequencies) for just 1-3 minutes and measured changes in alkaline phosphatase, an important enzyme involved in cellular metabolism. They found that specific pulse frequencies, particularly at 70 Hz, nearly doubled the enzyme's activity levels. This suggests that even brief exposures to common wireless frequencies can trigger measurable biological responses at the cellular level.