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Extremely low-frequency magnetic field induces manganese accumulation in brain, kidney and liver of rats

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Celik MS, Guven K, Akpolat V, Akdag MZ, Naziroglu M, Gul-Guven R, Celik MY, Erdogan S. · 2013

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Exposure to an extremely low-frequency magnetic field increased manganese accumulation in the brain, kidney, and liver of rats beyond levels caused by manganese alone.

Plain English Summary

Summary written for general audiences

Researchers studied whether extremely low-frequency magnetic field (ELF-MF) exposure affects how manganese accumulates in rat organs. A total of 40 rats were randomly divided into eight groups, with four groups also exposed to ELF-MF at 1.5 mT and 50 Hz for 4 hours, 5 days a week, over 45 days. Manganese levels in the brain, kidney, and liver were higher in groups that received both manganese and ELF-MF exposure than in groups that received manganese alone.

Why This Matters

The study used four control groups that received different oral manganese doses every 2 days for 45 days, and four parallel groups that received the same doses along with ELF-MF exposure. After the exposure period, organ tissue was analyzed for manganese levels using an inductively coupled plasma-optical emission spectrometer. Even without ELF-MF, manganese levels in the brain, kidney, and liver were higher in manganese-dosed groups than in the control group.

Exposure Details

Magnetic Field
1.5 mT
Source/Device
50 Hz
Exposure Duration
4 h for 5 days a week during 45 days

Exposure Context

This study used 1.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 8 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats.

A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15...

In result of the current study, we observed that Mn levels in brain, kidney and liver were higher in...

In conclusion, result of the current study showed that the ELF-MF induced manganese accumulation in kidney, liver and brain of rats.

Cite This Study
Celik MS, Guven K, Akpolat V, Akdag MZ, Naziroglu M, Gul-Guven R, Celik MY, Erdogan S. (2013). Extremely low-frequency magnetic field induces manganese accumulation in brain, kidney and liver of rats Toxicol Ind Health. 2013 Feb 28.doi.org/10.1177/0748233713480204.
Show BibTeX
@article{ms_2013_extremely_lowfrequency_magnetic_field_227,
  author = {Celik MS and Guven K and Akpolat V and Akdag MZ and Naziroglu M and Gul-Guven R and Celik MY and Erdogan S.},
  title = {Extremely low-frequency magnetic field induces manganese accumulation in brain, kidney and liver of rats},
  year = {2013},
  doi = {10.1177/0748233713480204},
  url = {https://journals.sagepub.com/doi/abs/10.1177/0748233713480204},
}
DOI: 10.1177/0748233713480204

Cited By (9 papers)

Quick Questions About This Study

The study examined manganese accumulation in the kidney, liver, and brain of rats.
Rats were exposed to ELF-MF at 1.5 mT and 50 Hz for 4 hours a day, 5 days a week, over 45 days.
Manganese levels in the brain, kidney, and liver were higher in groups exposed to both manganese and ELF-MF than in groups that received manganese without ELF-MF exposure.
A total of 40 rats were randomly divided into eight groups, with four groups receiving only manganese doses and four groups also receiving ELF-MF exposure.
The researchers concluded that ELF-MF induced manganese accumulation in the kidney, liver, and brain of rats.