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Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice.

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Pandey N, Giri S. · 2018

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RFR exposure led to extensive DNA damage and pre-meiotic arrest in germ cells, while melatonin supplementation diminished these effects.

Plain English Summary

Summary written for general audiences

Researchers exposed Swiss albino mice to RFR for 3 hours twice daily for 35 days and gave some mice melatonin at 5 mg/kg body weight per day. RFR-exposed mice showed extensive DNA damage, arrest in pre-meiotic spermatogenesis, low sperm count, and sperm head abnormalities. Biochemical assays revealed excess free radical generation and histological changes in testis and germ cells. Melatonin supplementation diminished or abolished these effects.

Why This Matters

The study investigated the effect of RFR GSM-type 900 MHz and melatonin on germ cell development during spermatogenesis. The authors concluded that melatonin inhibits pre-meiotic spermatogenesis arrest through its anti-oxidative potential and ability to improve DNA repair pathways.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 MHz Duration: 3 h twice/day for 35 days

Study Details

The present study investigated the effect of RFR Global System for Mobile communication (GSM) type, 900 MHz and melatonin supplementation on germ cell development during spermatogenesis.

Swiss albino mice were divided into four groups. One group received RFR exposure for 3 h twice/day f...

Extensive DNA damage in germ cells of RFR-exposed animals along with arrest in pre-meiotic stages of...

It can be concluded that melatonin inhibits pre-meiotic spermatogenesis arrest in male germ cells through its anti-oxidative potential and ability to improve DNA reparative pathways, leading to normal sperm count and sperm morphology in RFR-exposed animals.

Cite This Study
Pandey N, Giri S. (2018). Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice. Toxicol Ind Health. 34(5):315-327, 2018.
Show BibTeX
@article{n_2018_melatonin_attenuates_radiofrequency_radiation_1696,
  author = {Pandey N and Giri S.},
  title = {Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice.},
  year = {2018},
  doi = {10.1177/0748233718758092},
  url = {https://journals.sagepub.com/doi/abs/10.1177/0748233718758092},
}
DOI: 10.1177/0748233718758092

Cited By (51 papers)

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Quick Questions About This Study

One group received RFR exposure for 3 hours twice daily for 35 days, and another group received the same exposure with melatonin at 5 mg/kg body weight per day.
RFR-exposed animals showed extensive DNA damage, arrest in pre-meiotic stages of spermatogenesis, low sperm count, and sperm head abnormalities.
The effects were either diminished or absent in RFR-exposed animals supplemented with melatonin.
The authors concluded that melatonin inhibits pre-meiotic spermatogenesis arrest through its anti-oxidative potential and ability to improve DNA repair pathways.