Effects of 5-HT1 and 5-HT 2 Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats.
Ozdemir E, Demirkazik A, Taskıran AS, Arslan G. · 2019
View Original AbstractSerotonin 5-HT1 and 5-HT2 receptors play an important role in EMF-induced analgesia in rats, according to researchers.
Plain English Summary
Researchers exposed 66 adult male Wistar albino rats to alternating 50 Hz and 5 mT EMF for 2 hours a day for 15 days, then injected serotonin receptor agonists or antagonists before analgesia tests. Administration of serotonin HCl to MF-exposed rats produced a significant increase in percent maximal possible effect compared with the EMF group. Injection of WAY 100635 to MF-exposed rats produced a significant decrease in analgesic activity, while DOI hydrochloride significantly increased % MPE values compared with the EMF group. The researchers suggested that serotonin 5-HT1 and 5-HT2 receptors play an important role in EMF-induced analgesia, but noted that further research studies are necessary to understand the mechanism.
Why This Matters
The 5-HT1 agonist serotonin HCl was injected at 4 mg/kg, the 5-HT1 antagonist WAY 100635 at 0.04 mg/kg, the 5-HT2 receptor agonist DOI hydrochloride at 4 mg/kg, and the 5-HT2 antagonist SB 204741 at 0.5 mg/kg. Similarly, the 5-HT2 antagonist SB 204741 reduced % MPE values compared with the EMF group. Statistical analysis used analysis of variance, with multiple comparisons determined by Tukey's test.
Exposure Details
- Magnetic Field
- 5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 2 h a day for 15 days
Exposure Context
This study used 5 mT for magnetic fields:
- 250Kx above the Building Biology guideline of 0.2 mG
- 50Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor agonists (serotonin HCl and 2,5-dimethoxy-4-iodoamphetamine [DOI] hydrochloride) on EMF-induced analgesia.
In total, 66 adult male Wistar albino rats with an average body mass of 225 ± 13 g were used in this...
Administration of serotonin HCl MF (5 mT)-exposed rats produced a significant increase in percent ma...
In conclusion, our results suggested that serotonin 5-HT1 and 5-HT2 receptors play an important role in EMF-induced analgesia; however, further research studies are necessary to understand the mechanism. Bioelectromagnetics.
Show BibTeX
@article{e_2019_effects_of_5ht1_and_689,
author = {Ozdemir E and Demirkazik A and Taskıran AS and Arslan G.},
title = {Effects of 5-HT1 and 5-HT 2 Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats.},
year = {2019},
doi = {10.1002/bem.22196},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.22196},
}