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Cancer & Tumors

Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice.

No Effects Found

Heikkinen P, Kosma VM, Alhonen L, Huuskonen H, Komulainen H, Kumlin T, Laitinen JT, Lang S, Puranen L, Juutilainen J. · 2003

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Mobile phone radiation at legal limits didn't significantly increase skin cancer in mice, but slightly accelerated tumor development warrants further investigation.

Plain English Summary

Summary written for general audiences

Finnish researchers exposed mice to mobile phone radiation for one year while also exposing them to UV light to see if the combination would increase skin cancer rates. The mobile phone radiation alone did not significantly increase tumor development, though there was a slight acceleration in tumor growth timing that the researchers noted deserves further investigation.

Study Details

The effects of low-level radiofrequency radiation (RFR) on ultraviolet (UV)-induced skin tumorigenesis were evaluated in ornithine decarboxylase (ODC) and non-transgenic mice.

Transgenic female mice over-expressing the human ODC gene and their non-transgenic littermates (20 a...

UV exposure resulted in development of macroscopic skin tumours in 11.5 and 36.8% of non-transgenic ...

RFR exposures did not significantly enhance skin tumourigenesis. However, the slightly accelerated tumour development may warrant further evaluation.

Cite This Study
Heikkinen P, Kosma VM, Alhonen L, Huuskonen H, Komulainen H, Kumlin T, Laitinen JT, Lang S, Puranen L, Juutilainen J. (2003). Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice. Int J Radiat Biol 79(4):221-233, 2003.
Show BibTeX
@article{p_2003_effects_of_mobile_phone_3073,
  author = {Heikkinen P and Kosma VM and Alhonen L and Huuskonen H and Komulainen H and Kumlin T and Laitinen JT and Lang S and Puranen L and Juutilainen J.},
  title = {Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice.},
  year = {2003},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/12775446/},
}
PubMed: 12775446

Cited By (52 papers)

View all 52 citing papers on Semantic Scholar

Quick Questions About This Study

A 2003 Finnish study found that mobile phone radiation did not significantly increase skin cancer rates in mice exposed to UV light for one year. However, researchers noted a slight acceleration in tumor development timing that warrants further investigation.
Finnish researchers found that mobile phone radiation slightly accelerated skin tumor development in mice, particularly in non-transgenic animals. While not statistically significant, this accelerated timing effect was notable enough for researchers to recommend further evaluation.
In the 2003 study, transgenic mice developed skin tumors at higher rates (36.8%) compared to non-transgenic mice (11.5%) when exposed to UV light. However, mobile phone radiation did not significantly affect tumor development in either group.
The Finnish study found no effects of mobile phone radiation on 6-hydroxymelatonin sulphate excretion in mouse urine. This suggests that one-year exposure to mobile phone radiation did not disrupt melatonin metabolism in the test animals.
Researchers found no effects of mobile phone radiation on polyamine levels in mouse dorsal skin tissue. This indicates that radiofrequency exposure did not alter these important cellular compounds involved in cell growth and division.