Suppressive effect of electromagnetic field on analgesic activity of tramadol in rats
Bodera P, Stankiewicz W, Antkowiak B, Paluch M, Kieliszek J, Sobiech J, Zdanowski R, Wojdas A, Siwicki AK, Skopińska-Rózewska E · 2012
View Original AbstractElectromagnetic fields of 1500 and 1800 MHz did not affect pain perception on their own, but transiently suppressed the pain-relieving effect of tramadol in rats.
Plain English Summary
Researchers studied how high-frequency electromagnetic fields affect pain perception and the pain-relieving activity of tramadol in rats. Exposures at 1500 MHz and modulated 1800 MHz were applied, and paw withdrawal latency to a thermal stimulus was measured before and after injections of either tramadol or a vehicle. EMF exposure alone produced no differences in pain perception compared with controls, but EMF at both frequencies transiently suppressed the analgesic effect of tramadol at 30 minutes after drug injection.
Why This Matters
Tramadol alone significantly increased paw withdrawal latency to thermal stimulus compared with vehicle results at 30 minutes (p < 0.001) and 60 minutes (p < 0.05) after injection. When rats receiving tramadol were also exposed to EMF, the latency was significantly reduced at 30 minutes, suggesting the EMF transiently interfered with the drug's pain-relieving action. EMF at neither frequency altered pain thresholds when applied without the drug.
Exposure Details
- Magnetic Field
- 0.0003 and 0.000062 mT
- Electric Field
- 90 and 20 V/m
- Source/Device
- 1500 MHz and 1800 MHz(modulated)
- Exposure Duration
- 15 minutes
Exposure Context
This study used 90 and 20 V/m for electric fields:
- 66.7x above the Building Biology guideline of 0.3 V/m
This study used 0.0003 and 0.000062 mT for magnetic fields:
- 3.1x above the Building Biology guideline of 0.2 mG
- 0.6x above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this study was to evaluate the influence of electromagnetic fields of high-frequency microwaves on pain perception and anti-nociceptive activity of tramadol (TRAM) - analgetic effective in the treatment of moderate to severe acute and chronic pain states.
Electromagnetic fields exposures of a)1500 MHz frequency and b) modulated, 1800 MHz (which is identi...
The differences in the level of pain (PWL) between control group and rats exposed to EMF alone in th...
High frequency electromagnetic fields of 1500 and 1800 MHz when applied alone, did not influence pain perception threshold to thermal stimulus, however it presented an unwanted effect diminishing analgesic action of tramadol
Show BibTeX
@article{p_2012_suppressive_effect_of_electromagnetic_70,
author = {Bodera P and Stankiewicz W and Antkowiak B and Paluch M and Kieliszek J and Sobiech J and Zdanowski R and Wojdas A and Siwicki AK and Skopińska-Rózewska E},
title = {Suppressive effect of electromagnetic field on analgesic activity of tramadol in rats},
year = {2012},
url = {http://journals.pan.pl/dlibra/show-content?id=99012&},
}