6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.

Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state

Bioeffects Seen

Bodera P, Stankiewicz W, Zawada K, Antkowiak B, Paluch M, Kieliszek J, Kalicki B, Bartosiński A, Wawer I · 2013

View Original Abstract
Share:

Single EMF exposure at 1800 MHz significantly reduced antioxidant capacity in both healthy rats and those with paw inflammation.

Plain English Summary

Summary written for general audiences

Some rats had persistent inflammation induced by CFA injection 24 hours before exposure. Rats received tramadol at 20 mg/kg or vehicle before exposure. Single EMF exposure significantly reduced antioxidant capacity in both healthy and inflamed rats. A synergistic effect between EMF and tramadol was observed in CFA-treated rats.

Why This Matters

The study aimed to observe changes in antioxidant capacity from the combined action of 1800 MHz electromagnetic fields and tramadol in a persistent inflammatory model. Healthy rats had higher antioxidant capacity than rats that received tramadol and were exposed to electromagnetic fields. Inflammation was induced by injecting CFA into the plantar surface of the left hind paw.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 1800 MHz Duration: 15 min

Study Details

The aim of this study is to observe Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state

Experiments were performed in healthy rats and in rats with persistent inflammatory state induced by...

Our study revealed that single EMF exposure in 1800 MHz frequency significantly reduced antioxidant ...

The aim of the study was to examine the possible, parallel/combined effects of electromagnetic radiation, artificially induced inflammation and a centrally-acting synthetic opioid analgesic drug, tramadol, (used in the treatment of severe pain) on the antioxidant capacity of blood of rats. The antioxidant capacity of blood of healthy rats was higher than that of rats which received only tramadol and were exposed to electromagnetic fields.

Cite This Study
Bodera P, Stankiewicz W, Zawada K, Antkowiak B, Paluch M, Kieliszek J, Kalicki B, Bartosiński A, Wawer I (2013). Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state Pharmacol Rep. 65(2):421-428, 2013.
Show BibTeX
@article{p_2013_changes_in_antioxidant_capacity_1619,
  author = {Bodera P and Stankiewicz W and Zawada K and Antkowiak B and Paluch M and Kieliszek J and Kalicki B and Bartosiński A and Wawer I},
  title = {Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state},
  year = {2013},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S173411401371017X},
}

Quick Questions About This Study

The study used 1800 MHz electromagnetic fields with 15 minutes of exposure.
Persistent inflammation was induced by injecting Complete Freund's Adjuvant into the plantar surface of the left hind paw 24 hours before exposure.
Rats were injected intraperitoneally with tramadol at a dose of 20 mg/kg immediately before EMF exposure.
Single EMF exposure at 1800 MHz significantly reduced antioxidant capacity in healthy animals.
A synergistic mode of action between electromagnetic fields and tramadol was observed in rats treated with CFA.