Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus
Manikonda PK, Rajendra P, Devendranath D, Gunasekaran B, Channakeshava, Aradhya RS, Sashidhar RB, Subramanyam C. · 2007
View Original AbstractELF magnetic field exposure in rats was associated with altered calcium signaling and decreased NMDA receptor binding in the hippocampus.
Plain English Summary
Researchers exposed rats to 50 Hz magnetic fields at 50 and 100 μT intensities for 90 days and then examined hippocampal tissue. Compared to controls, ELF exposure was associated with increased intracellular calcium levels and changes in the activity of several calcium-related enzymes. Binding to NMDA receptors was also found to be decreased in exposed rats. The researchers suggested that perturbed neuronal functions caused by ELF exposure may involve altered calcium signaling contributing to aberrant NMDA receptor activities.
Why This Matters
The researchers focused on calcium signaling because ELF magnetic fields are associated with altered calcium balance in neural tissues. Among the enzyme changes, PKC activity and cAMP-dependent protein kinase activity increased, while calcium-calmodulin-dependent protein kinase activity decreased.
Exposure Details
- Magnetic Field
- 0.05, 0.1 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 90 days
Exposure Context
This study used 0.05, 0.1 mT for magnetic fields:
- 2.5Kx above the Building Biology guideline of 0.2 mG
- 500x above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
Extremely low frequency (ELF < 300 Hz) electromagnetic fields affect several neuronal activities including memory. Because ELF magnetic fields cause altered Ca2+ homeostasis in neural tissues, we examined their influence on Ca2+ signaling enzymes in hippocampus and related them with NMDA receptor functions.
Hippocampal regions were obtained from brains of 21-day-old rats that were exposed for 90 days to 50...
In comparison to controls, ELF exposure caused increased intracellular Ca2+ levels concomitant with...
The combined results suggest that perturbed neuronal functions caused by ELF exposure may involve altered Ca2+ signaling events contributing to aberrant NMDA receptor activities.
Show BibTeX
@article{pk_2007_influence_of_extremely_low_278,
author = {Manikonda PK and Rajendra P and Devendranath D and Gunasekaran B and Channakeshava and Aradhya RS and Sashidhar RB and Subramanyam C.},
title = {Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus},
year = {2007},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0304394006012833},
}