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Brain & Nervous System109 citations

Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons.

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Di Loreto S, Falone S, Caracciolo V, Sebastiani P, D'Alessandro A, Mirabilio A, Zimmitti V, Amicarelli F. · 2009

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ELF magnetic field exposure positively affected cell viability and reduced apoptotic death in rat neuronal primary cultures, with no significant effects on the main antioxidative defences.

Plain English Summary

Summary written for general audiences

Researchers investigated the effects of exposures to two different 50 Hz sinusoidal ELF magnetic field intensities, 0.1 and 1 mT, on maturing rat cortical neurons. Exposure positively affected cell viability and reduced apoptotic death, with no significant effects on the main antioxidative defences. Linear regression analysis suggested a positive correlation between reduced glutathione and ROS levels in 1 mT magnetic-field-exposed cells. The researchers also observed brain-derived neurotrophic factor over-expression and interleukin 1β-dependent regulation of pro-survival signaling pathways following exposure.

Why This Matters

The study examined antioxidative enzymatic and non-enzymatic cellular protection systems, membrane peroxidative damage, and growth factor and cytokine expression in maturing rat cortical neurons. Despite no significant effects on the main antioxidative defences overall, the researchers proposed that reduced glutathione could play an important role in antioxidant defence towards the ELF-MF-induced redox challenge.

Exposure Details

Magnetic Field
0.1 and 1 mT
Source/Device
50 Hz

Exposure Context

This study used 0.1 and 1 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1 and 1 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of the present work was to investigate the effects of exposures to two different 50 Hz sinusoidal ELF‐MFs intensities (0.1 and 1 mT) in maturing rat cortical neurons' major anti‐oxidative enzymatic and non‐enzymatic cellular protection systems, membrane peroxidative damage, as well as growth factor, and cytokine expression pattern.

Briefly, our results showed that ELF‐MFs affected positively the cell viability and concomitantly re...

Cite This Study
Di Loreto S, Falone S, Caracciolo V, Sebastiani P, D'Alessandro A, Mirabilio A, Zimmitti V, Amicarelli F. (2009). Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons. J Cell Physiol. 219(2):334-343, 2009.
Show BibTeX
@article{s_2009_fifty_hertz_extremely_lowfrequency_242,
  author = {Di Loreto S and Falone S and Caracciolo V and Sebastiani P and D'Alessandro A and Mirabilio A and Zimmitti V and Amicarelli F.},
  title = {Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons.},
  year = {2009},
  doi = {10.1002/jcp.21674},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.21674},
}
DOI: 10.1002/jcp.21674

Cited By (109 papers)

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Quick Questions About This Study

The study used maturing rat cortical neurons in primary cultures.
Two intensities were tested: 0.1 and 1 mT, both sinusoidal at 50 Hz.
Exposure positively affected cell viability and reduced levels of apoptotic death in the neuronal cultures.
Researchers observed brain-derived neurotrophic factor over-expression following magnetic field exposure.
The researchers hypothesised that reduced glutathione could play an important role in antioxidant defence towards the ELF-MF-induced redox challenge.