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[Effects of GSM 1800 MHz radiofrequency electromagnetic fields on protein expression profile of human breast cancer cell MCF-7.]

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Zeng QL, Weng Y, Chen GD, Lu DQ, Chiang H, Xu ZP · 2006

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The study found differential protein expression after 3-hour intermittent and 12-hour continuous GSM 1800 MHz exposure, but not after 6-hour continuous exposure.

Plain English Summary

Summary written for general audiences

Researchers exposed MCF-7 human breast cancer cells to GSM 1800 MHz RF EMF at 3.5 W/kg SAR for various durations and modes. They used 2-dimensional electrophoresis and PDQuest software to analyze protein expression. No differential proteins were found after 6 hours of continuous exposure. Eighteen differential proteins were detected after 3-hour intermittent exposure and seven after 12-hour continuous exposure. The analysis suggested that the differentially expressed proteins should be related to biosynthesization, signal transduction, and DNA damage and repair.

Why This Matters

The study detected around 1100 proteins using pH 4-7 IPG strips. Protein expression changes might depend on exposure duration and mode. Each experiment was repeated three times.

Exposure Details

SAR
3.5 W/kg
Exposure Duration
5 minutes field on followed by 10 minutes off) exposed to RF EMF for different duration (1 hour, 3 hours, 6 hours, 12 hours, or 24 hours

Exposure Context

This study used 3.5 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 3.5 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 2 times the FCC limit

Study Details

To study the effects of GSM 1800 MHz radiofrequency electromagnetic fields (RF EMF) exposure on protein expression profile of human breast cancer cell line (MCF-7), as to exploring the possible effects on normal cell physiological function.

MCF-7 cells were continuously or intermittently (5 minutes field on followed by 10 minutes off) expo...

On the average, around 1100 proteins were detected using pH 4 - 7 IPG strip. There were no different...

Data indicated that the protein expression changes induced by RF radiation might depend on exposure duration and mode. Many biological processes might be affected by RF exposure.

Cite This Study
Zeng QL, Weng Y, Chen GD, Lu DQ, Chiang H, Xu ZP (2006). [Effects of GSM 1800 MHz radiofrequency electromagnetic fields on protein expression profile of human breast cancer cell MCF-7.] Zhonghua Yu Fang Yi Xue Za Zhi. 40(3):153-158, 2006.
Show BibTeX
@article{ql_2006_effects_of_gsm_1800_1456,
  author = {Zeng QL and Weng Y and Chen GD and Lu DQ and Chiang H and Xu ZP},
  title = {[Effects of GSM 1800 MHz radiofrequency electromagnetic fields on protein expression profile of human breast cancer cell MCF-7.]},
  year = {2006},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/16836875/},
}
PubMed: 16836875

Cited By (4 papers)

Quick Questions About This Study

MCF-7 cells were exposed continuously or intermittently (5 minutes on, 10 minutes off) for 1, 3, 6, 12, or 24 hours at 3.5 W/kg SAR.
Around 1100 proteins were detected using pH 4-7 IPG strips.
No differential proteins were found under continuous exposure at SAR 3.5 W/kg for 6 hours.
The analysis suggested that the differentially expressed proteins should be related to biosynthesization, signal transduction, and DNA damage and repair.
Each experiment was repeated three times.