Effects of 60 Hz magnetic field exposure on polymorphonuclear leukocyte activation.
Khadir R, Morgan JL, Murray JJ. · 1999
View Original AbstractExposing human neutrophils to a 22 mT, 60 Hz magnetic field increased superoxide anion production and β-glucuronidase release when cells were also stimulated with PMA, but had no effect on resting cells.
Plain English Summary
Researchers investigated the effects of a sinusoidal 60 Hz magnetic field on free radical production, degranulation, and viability in human neutrophils. Exposure of unstimulated human neutrophils to the magnetic field did not affect the functions examined. When cells were also stimulated with PMA, exposure to a 22 mT, 60 Hz magnetic field induced significant increases in superoxide anion production of 26.5% and in β-glucuronidase release of 53%. Release of lysozyme and lactate dehydrogenase was unchanged by the magnetic field, whether the cells were stimulated or not.
Why This Matters
The experiments were performed blindly under controlled conditions, examining resting neutrophils and neutrophils stimulated with a tumor promoter called phorbol 12-myristate 13-acetate (PMA). The magnetic field did not affect superoxide anion generation by a cell-free system using xanthine and xanthine oxidase, which the researchers said suggests the magnetic field could upregulate common cellular events leading to superoxide anion generation and β-glucuronidase release. The researchers concluded that the effect of the magnetic field on stimulated cells could be the result of an alteration in intracellular signaling.
Exposure Details
- Magnetic Field
- 22 mT
- Source/Device
- 60 Hz
Exposure Context
This study used 22 mT for magnetic fields:
- 1.1Mx above the Building Biology guideline of 0.2 mG
- 220Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We have investigated the effects of a sinusoidal 60 Hz magnetic field on free radical (superoxide anion) production, degranulation (β-glucuronidase and lysozyme release) and viability in human neutrophils (PMNs).
Experiments were performed blindly in very controlled conditions to examine the effects of a magneti...
Exposure of unstimulated human PMNs to a 60 Hz magnetic field did not affect the functions examined....
In conclusion, exposure of PMNs to a 22 mT, 60 Hz magnetic field potentiates the effect of PMA on O2− generation and β-glucuronidase release. This effect could be the result of an alteration in the intracellular signaling.
Show BibTeX
@article{r_1999_effects_of_60_hz_398,
author = {Khadir R and Morgan JL and Murray JJ.},
title = {Effects of 60 Hz magnetic field exposure on polymorphonuclear leukocyte activation.},
year = {1999},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0304416599001427},
}