Connection between Cell Phone use, p53 Gene Expression in Different Zones of Glioblastoma Multiforme and Survival Prognoses.
Akhavan-Sigari R, Baf MM, Ariabod V, Rohde V, Rahighi S. · 2014
View Original AbstractHeavy cell phone users (3+ hours daily) showed dangerous genetic mutations in 65% of brain tumors, linked to shorter survival.
Plain English Summary
Researchers studied brain tumor tissue from 63 patients with glioblastoma multiforme (the most aggressive type of brain cancer) to see if cell phone use affected gene expression. They found that patients who used cell phones for 3 or more hours daily had significantly higher levels of mutated p53 genes in their tumors - a marker associated with cancer progression and shorter survival times. This suggests heavy cell phone use may influence how aggressive these brain cancers become at the genetic level.
Why This Matters
This study provides compelling evidence that heavy cell phone use doesn't just potentially increase brain cancer risk - it may also influence how aggressive these cancers become once they develop. The p53 gene acts as a cellular 'guardian' that normally prevents cancer formation, and when it mutates, tumors become more dangerous and harder to treat. What makes this research particularly significant is that it examined actual tumor tissue from patients, not just laboratory cells or animal models. The 3-hour daily threshold represents heavy but not uncommon usage patterns - many people today easily exceed this with streaming, gaming, and extended calls. The fact that 65% of heavy users showed these genetic changes suggests a clear dose-response relationship. While this study alone doesn't prove causation, it adds important molecular evidence to the growing body of research linking RF radiation exposure to brain cancer progression.
Exposure Information
Specific exposure levels were not quantified in this study. Duration: ≥3 hours/day
Study Details
The aim of this paper is to investigate p53 gene expression in the central and peripheral zones of glioblastoma multiforme using a real-time reverse transcription polymerase chain reaction (RT-PCR) technique in patients who use cell phones ≥3 hours a day and determine its relationship to clinicopathological findings and overall survival.
Sixty-three patients (38 males and 25 females), diagnosed with glioblastoma multiforme (GBM), underw...
Forty-one out of 63 patients (65%) with the highest level of cell phone use (≥3 hours/day) had highe...
We found that the mutant type of p53 gene expression in the peripheral zone of the glioblastoma was increased in 65% of patients using cell phones ≥3 hours a day.
Show BibTeX
@article{r_2014_connection_between_cell_phone_1816,
author = {Akhavan-Sigari R and Baf MM and Ariabod V and Rohde V and Rahighi S.},
title = {Connection between Cell Phone use, p53 Gene Expression in Different Zones of Glioblastoma Multiforme and Survival Prognoses.},
year = {2014},
url = {https://pubmed.ncbi.nlm.nih.gov/25276320/},
}