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Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3.

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Varghese R, Majumdar A, Kumar G, Shukla A. · 2017

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Female Sprague Dawley rats exposed to 2.45GHz radiation for 4 hours daily over 45 days showed memory decline and anxiety behavior in behavioral tests.

Plain English Summary

Summary written for general audiences

Researchers exposed female Sprague Dawley rats to 2.45GHz radiation for 4 hours per day for 45 days and assessed behavioral and oxidative stress parameters. Exposed rats exhibited memory decline and anxiety behavior in the Morris water maze, elevated plus maze, and light-dark box tests. Radiation exposure decreased brain antioxidant enzymes superoxide dismutase, catalase, and reduced glutathione, increased lipid peroxidation, and increased the apoptotic marker caspase 3, while histopathological examination and TNF-α levels showed no significant changes.

Why This Matters

Analysis of dendritic arborization revealed reduced dendritic branching and intersections, indicating altered neuronal structure and signaling. Oxidative stress parameters were measured in brain homogenates after the rats were sacrificed on day 45.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2.45GHz Duration: 4h/day for 45days

Study Details

The present study evaluated the impact of 2.45GHz radiation exposure for 4h/day for 45days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38.

Oxidative stress parameters were estimated in brain homogenates after sacrificing the rats on day 45...

In morris water maze, elevated plus maze and light dark box test, the 2.45GHz radiation exposed rats...

The study clearly indicates that exposure of rats to microwave radiation of 2.45GHz leads to detrimental changes in brain leading to lowering of learning and memory and expression of anxiety behavior in rats along with fall in brain antioxidant enzyme systems.

Cite This Study
Varghese R, Majumdar A, Kumar G, Shukla A. (2017). Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3. Pathophysiology. 2017 Nov 14. pii: S0928-4680(17)30052-4. doi: 10.1016/j.pathophys.2017.11.001.
Show BibTeX
@article{r_2017_rats_exposed_to_245ghz_1718,
  author = {Varghese R and Majumdar A and Kumar G and Shukla A.},
  title = {Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/29153770/},
}
PubMed: 29153770

Cited By (42 papers)

Quick Questions About This Study

Female Sprague Dawley rats were exposed to 2.45GHz radiation for 4 hours per day for 45 days.
Exposed rats showed memory decline and anxiety behavior in the Morris water maze, elevated plus maze, and light-dark box tests.
Exposure decreased superoxide dismutase, catalase, and reduced glutathione, increased lipid peroxidation, and increased caspase 3 expression in the brain.
No significant changes were observed in histopathological examinations or brain TNF-α levels.
Dendritic arborization analysis showed reduced dendritic branching and intersections, indicating altered neuronal structure.