Role of Sod Gene in Response to Static Magnetic Fields in Pseudomonas aeruginosa
Hanini R, Chatti A, Ghorbel SB, Landoulsi A. · 2017
View Original AbstractSuperoxide dismutase played a protective role against stress induced by a static magnetic field in Pseudomonas aeruginosa.
Plain English Summary
Researchers studied the protective role of superoxide dismutase (SOD) against a static magnetic field of 200 mT in wild-type and mutant strains of Pseudomonas aeruginosa lacking one or both SOD enzymes. Inactivation of the sodM and/or sodB genes increased the sensitivity of the bacteria to stress from the static magnetic field. Mutant strains also showed significantly higher levels of malondialdehyde, a marker of oxidative damage to lipids, compared to wild-type cells.
Why This Matters
The study compared bacteria that naturally produce SOD enzymes with mutant strains engineered to lack Mn-SOD, Fe-SOD, or both. Exposure to the magnetic field enhanced SOD, catalase, and peroxidase activity, suggesting the bacteria mount an antioxidant response. Wild-type cells, which retained their SOD genes, maintained significantly higher antioxidant enzyme activities than the mutant strains. The elevated malondialdehyde in mutant strains points to greater oxidative damage when SOD enzymes are absent.
Exposure Details
- Magnetic Field
- 200 mT
Exposure Context
This study used 200 mT for magnetic fields:
- 10Mx above the Building Biology guideline of 0.2 mG
- 2Mx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The protective role of superoxide dismutase (SOD) against non-ionizing radiation such as static electromagnetic field (200 mT) has been studied in wild-type and mutant strain of Pseudomonas aeruginosa lacking cytosolic Mn-SOD (sodM), Fe-SOD (sodB), or both SODs (sodMB).
Our results showed that inactivation of sodM and/or sodB genes increases the sensitivity of P. aerug...
The overall results showed that the SOD has a protective role against a stress induced by static electromagnetic field in P. aeruginosa.
Show BibTeX
@article{r_2017_role_of_sod_gene_383,
author = {Hanini R and Chatti A and Ghorbel SB and Landoulsi A. },
title = {Role of Sod Gene in Response to Static Magnetic Fields in Pseudomonas aeruginosa},
year = {2017},
doi = {10.1007/s00284-017-1264-4},
url = {https://link.springer.com/article/10.1007/s00284-017-1264-4},
}