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Oxidative Stress

Evaluation of inflammatory biomarkers associated with oxidative stress and histological assessment of magnetic therapy on experimental myopathy in rats.

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Vignola MB, Dávila S, Cremonezzi D, Simes JC, Palma JA, Campana VR · 2012

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Pulsed electromagnetic field therapy reduced inflammatory biomarkers and promoted muscle recovery in rats with experimentally induced myopathy.

Plain English Summary

Summary written for general audiences

Researchers evaluated the effect of pulsed electromagnetic field (PEMF) therapy on inflammatory biomarkers associated with oxidative stress in rats with experimental myopathy. Myopathy was induced by injecting 50 μl of 1% carrageenan, and PEMF treatment was applied at 20 mT and 50 Hz for 30 min/day/rat. PEMF treatment was associated with decreased levels of fibrinogen, L-citrulline, NO, SOD, and carbonyl groups and significant muscle recovery.

Why This Matters

The groups studied included intact rats receiving sham PEMF exposures, rats with myopathy sacrificed 24 h later, rats with myopathy without treatment, rats with myopathy treated with PEMF, and intact rats treated with PEMF. In the myopathy groups without PEMF treatment, the biomarkers were significantly increased compared to other groups, including fibrinogen (p < 0.001), NO, L-citrulline, and carbonyl groups (p < 0.05), and SOD (p < 0.01). The percentage of area with inflammatory infiltration was also significantly higher in the untreated myopathy groups (p < 0.001). Biomarkers were measured by spectrophotometry, and muscle tissue was stained with Hematoxylin-Eosin and examined by optic microscopy.

Exposure Details

Magnetic Field
20 mT
Source/Device
50 Hz
Exposure Duration
30 min/day for 8 consecutive days

Exposure Context

This study used 20 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 20 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 100 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The effect of pulsed electromagnetic field (PEMF) therapy, also called magnetic therapy, upon inflammatory biomarkers associated with oxidative stress plasma fibrinogen, nitric oxide (NO), L-citrulline, carbonyl groups, and superoxide dismutase (SOD) was evaluated through histological assessment, in rats with experimental myopathy.

The groups studied were: (A) control (intact rats that received PEMF sham exposures); (B) rats with ...

In Groups B and C, the biomarkers were significantly increased compared to A, D, and E groups: fibri...

PEMF caused decreased levels of fibrinogen, L-citrulline, NO, SOD, and carbonyl groups and significant muscle recovery in rats with experimental myopathies.

Cite This Study
Vignola MB, Dávila S, Cremonezzi D, Simes JC, Palma JA, Campana VR (2012). Evaluation of inflammatory biomarkers associated with oxidative stress and histological assessment of magnetic therapy on experimental myopathy in rats. Electromagn Biol Med. 31(4):320-332. 2012.
Show BibTeX
@article{mb_2012_evaluation_of_inflammatory_biomarkers_477,
  author = {Vignola MB and Dávila S and Cremonezzi D and Simes JC and Palma JA and Campana VR},
  title = {Evaluation of inflammatory biomarkers associated with oxidative stress and histological assessment of magnetic therapy on experimental myopathy in rats.},
  year = {2012},
  doi = {10.3109/15368378.2011.641706},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2011.641706},
}
DOI: 10.3109/15368378.2011.641706

Cited By (8 papers)

Quick Questions About This Study

The study used pulsed electromagnetic field (PEMF) therapy delivered at 20 mT and 50 Hz for 30 minutes per day per rat.
Researchers measured plasma fibrinogen, nitric oxide, L-citrulline, carbonyl groups, and superoxide dismutase as inflammatory biomarkers associated with oxidative stress.
Myopathy was induced by injecting 50 μl of 1% carrageenan λ (type IV) once sub-plantar.
PEMF treatment caused decreased levels of fibrinogen, L-citrulline, NO, SOD, and carbonyl groups in rats with experimental myopathies.
Muscle tissues were stained with Hematoxylin-Eosin and examined by optic microscopy.