Effect of exposure to 50 Hz magnetic field with or without insulin on blood-brain barrier permeability in streptozotocin-induced diabetic rats.
Gulturk S, Demirkazik A, Kosar I, Cetin A, Dökmetas HS, Demir T · 2010
View Original AbstractIn diabetic rats, 50 Hz magnetic field exposure and diabetes each increased blood-brain barrier permeability, and together they caused a greater increase than either alone.
Plain English Summary
Rats in the magnetic field groups were exposed to a 5 mT field for 165 minutes every day for 30 days, and all rats underwent Evans blue measurement to evaluate the blood-brain barrier. Diabetes and magnetic field exposure each increased blood-brain barrier permeability, their combination caused a greater increase, and insulin reduced that effect.
Why This Matters
Evans blue extravasation was higher in the magnetic field, diabetes, and combined groups compared with the sham group, and the right hemisphere of the group receiving both diabetes, insulin, and magnetic field exposure showed the highest extravasation. Body mass after the procedure was significantly higher in the sham and magnetic field-only groups than in the diabetic groups. In all diabetic groups, blood glucose was significantly lower at baseline than after the procedure. The researchers noted that diabetes increased mean arterial blood pressure, but magnetic field exposure caused no additional effect on blood pressure.
Exposure Details
- Magnetic Field
- 5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 65 min every day for 30 days
Exposure Context
This study used 5 mT for magnetic fields:
- 250Kx above the Building Biology guideline of 0.2 mG
- 50Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We investigated the effect of long‐term exposure to modulation magnetic field (MF), insulin, and their combination on blood–brain barrier (BBB) permeability in a diabetic rat model.
Fifty‐three rats were randomly assigned to one of six groups: sham, exposed to no MF; MF, exposed to...
The extravasation of brain EB of the MF, DM, DMMF, DMI, and DMIMF groups was higher than that of the...
Show BibTeX
@article{s_2010_effect_of_exposure_to_254,
author = {Gulturk S and Demirkazik A and Kosar I and Cetin A and Dökmetas HS and Demir T},
title = {Effect of exposure to 50 Hz magnetic field with or without insulin on blood-brain barrier permeability in streptozotocin-induced diabetic rats.},
year = {2010},
doi = {10.1002/bem.20557},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20557},
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