Large gradient high magnetic field affects FLG29.1 cells differentiation to form osteoclast-like cells.
Di S, Tian Z, Qian A, Li J, Wu J, Wang Z, Zhang D, Yin D, Brandi ML, Shang P. · 2012
View Original AbstractHigh magnetic fields directly altered bone cell survival and development, demonstrating that magnetic fields can influence fundamental cellular processes.
Plain English Summary
Researchers exposed human bone cells (osteoclasts) to large gradient high magnetic fields for 72 hours to simulate different gravity conditions. They found that reduced apparent gravity conditions enhanced the formation of bone-destroying cells, while high magnetic flux inhibited their formation. This suggests that magnetic fields can directly affect bone cell development and survival.
Why This Matters
This research reveals something important about how magnetic fields interact with our bone cells at the cellular level. While the study used extremely high magnetic fields to simulate gravity conditions rather than everyday EMF exposure, it demonstrates that magnetic fields can directly influence fundamental cellular processes involved in bone health. The finding that different magnetic field conditions affected both cell survival and the formation of osteoclasts (cells that break down bone tissue) adds to our understanding of how electromagnetic fields interact with biological systems. What this means for you is that magnetic fields aren't biologically inert - they can trigger measurable changes in how our cells function and develop, even at the most basic level of bone formation.
Exposure Information
Specific exposure levels were not quantified in this study. Duration: 72 h
Study Details
We aimed to investigate the effects of different apparent gravities (μ g, 1 g and 2 g) produced by large gradient high magnetic field (LGHMF) on human preosteoclast FLG29.1 cells.
FLG29.1 cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium. Cells were expose...
MTT detection revealed that compared to control, FLG 29.1 cell proliferation in the μ g and 2 g grou...
These findings indicate that LGHMF could directly affect human preosteoclast FLG29.1 cells survival and differentiation. High magnetic flux inhibited osteoclasts formation and differentiation while reduced apparent gravity enhanced osteoclastogenesis.
Show BibTeX
@article{s_2012_large_gradient_high_magnetic_1584,
author = {Di S and Tian Z and Qian A and Li J and Wu J and Wang Z and Zhang D and Yin D and Brandi ML and Shang P.},
title = {Large gradient high magnetic field affects FLG29.1 cells differentiation to form osteoclast-like cells.},
year = {2012},
doi = {10.3109/09553002.2012.698365},
url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2012.698365},
}