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Brain & Nervous System

Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia.

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Rauš S, Selaković V, Manojlović-Stojanoski M, Radenović L, Prolić Z, Janać B. · 2013

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In gerbils with brain ischemia, exposure to an extremely low-frequency magnetic field was associated with significantly lower neuronal cell loss in the hippocampus on the seventh day after reperfusion.

Plain English Summary

Summary written for general audiences

Researchers studied whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, gerbils were continuously exposed to ELF-MF at an average magnetic induction of 0.5 mT for 7 days, with outcomes assessed on the seventh and 14th days after reperfusion. Ischemic gerbils exposed to ELF-MF had significantly lower cell loss and greater astrocyte and microglial responses compared with ischemic gerbils without exposure on the seventh day after reperfusion. By the 14th day after reperfusion, differences in the measured parameters were low and insignificant.

Why This Matters

The 10-min global cerebral ischemia led to neuronal death, especially in the CA1 region of the hippocampus. The researchers used stereological methods to assess hippocampal volume, volume densities of degenerating neurons and astrocytes, and the number of microglial cells per unit area. The researchers suggested that the applied ELF-MF has a possible neuroprotective function in the hippocampus through reduction of neuronal death and activation of astrocytes and microglial cells.

Exposure Details

Magnetic Field
0.5 mT
Source/Device
50 Hz
Exposure Duration
7 days

Exposure Context

This study used 0.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils.

After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average m...

ELF-MF per se did not induce any morphological changes, while 10-min global cerebral ischemia led to...

Cite This Study
Rauš S, Selaković V, Manojlović-Stojanoski M, Radenović L, Prolić Z, Janać B. (2013). Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia. Neurotox Res. 23(1):79-91, 2013.
Show BibTeX
@article{s_2013_response_of_hippocampal_neurons_284,
  author = {Rauš S and Selaković V and Manojlović-Stojanoski M and Radenović L and Prolić Z and Janać B. },
  title = {Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia.},
  year = {2013},
  doi = {10.1007/s12640-012-9333-8},
  url = {https://link.springer.com/article/10.1007/s12640-012-9333-8},
}
DOI: 10.1007/s12640-012-9333-8

Cited By (40 papers)

View all 40 citing papers on Semantic Scholar

Quick Questions About This Study

The study used an extremely low-frequency magnetic field at 50 Hz, with an average magnetic induction of 0.5 mT at the center of the cage.
Ischemic gerbils exposed to ELF-MF had significantly lower cell loss and greater responses of astrocytes and microglial cells than postischemic gerbils without exposure on the seventh day after reperfusion.
The hippocampus was the focus, described as the most sensitive brain structure in the model of global cerebral ischemia, with particular neuronal death observed in its CA1 region.