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Oxidative Stress

Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59.

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Türedi S, Kerimoğlu G, Mercantepe T, Odacı E. · 2017

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Continuous exposure to 900-MHz EMF for one hour daily from postnatal days 22 to 59 increased oxidative stress and caused pathological changes in male rat kidney and bladder tissues.

Plain English Summary

Summary written for general audiences

Malondialdehyde levels increased in the EMF group compared to both control and sham groups in kidney and bladder tissues, while catalase and glutathione levels decreased. Kidney tissue in the EMF group showed dilatation and vacuolization in tubules, glomerular degeneration, and increased apoptotic cells. Bladder tissue in the EMF group showed degeneration in the transitional epithelium, stromal irregularity, and increased apoptotic cells. Transmission electron microscopy revealed glomerular capillary degeneration with capillary basement membranes in the EMF group.

Why This Matters

The study used a control group with no procedure, a sham group placed in the exposure cage without EMF, and an EMF group exposed to 900-MHz fields. Tissues were examined using light microscopy with H&E and Masson trichrome staining, the TUNEL assay for apoptosis, and transmission electron microscopy for kidney tissue. Biochemical analysis measured oxidant and antioxidant parameters.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900-MHz Duration: 1 h a day on postnatal days 22–59, inclusive

Study Details

To investigate the effect on male rat kidney and bladder tissues of exposure to 900-megahertz (MHz) electromagnetic field (EMF) applied on postnatal days 22–59, inclusive

Twenty-four male Sprague Dawley rats, aged 21 days, were used. These were divided equally into one o...

The findings showed that tissue malondialdehyde increased in EMFG compared to CG and SG in both kidn...

We conclude that continuous exposure to the effect of 900-MHz EMF for 1 h a day on postnatal days 22–59, inclusive, causes an increase in oxidative stress and various pathological changes in male rat kidney and bladder tissues.

Cite This Study
Türedi S, Kerimoğlu G, Mercantepe T, Odacı E. (2017). Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59. Int J Radiat Biol. 93(9):990-999, 2017.
Show BibTeX
@article{s_2017_biochemical_and_pathological_changes_1715,
  author = {Türedi S and Kerimoğlu G and Mercantepe T and Odacı E.},
  title = {Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59.},
  year = {2017},
  doi = {10.1080/09553002.2017.1350768},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553002.2017.1350768},
}
DOI: 10.1080/09553002.2017.1350768

Cited By (24 papers)

Quick Questions About This Study

Rats were exposed to continuous 900-MHz EMF for one hour daily from postnatal days 22 to 59.
Malondialdehyde increased in kidney and bladder tissues, while catalase and glutathione levels decreased compared to control and sham groups.
Kidney tissue showed tubular dilatation and vacuolization, glomerular degeneration, and increased apoptotic cells; bladder tissue showed transitional epithelium degeneration, stromal irregularity, and increased apoptotic cells.
Researchers used H&E and Masson trichrome staining for histology, the TUNEL method for apoptosis, and transmission electron microscopy for kidney tissue.
Continuous 900-MHz EMF exposure for one hour daily during postnatal development increased oxidative stress and caused pathological changes in male rat kidney and bladder tissues.