Simultaneous application of cisplatin and static magnetic field enhances oxidative stress in HeLa cell line
Kamalipooya S, Abdolmaleki P, Salemi Z, Javani Jouni F, Zafari J, Soleimani H. · 2017
View Original AbstractStatic magnetic fields at 10 mT enhanced cancer cell death by 89% when combined with chemotherapy while sparing normal cells.
Plain English Summary
Researchers tested static magnetic fields combined with chemotherapy drug cisplatin on cancer cells. The magnetic fields enhanced cisplatin's cancer-killing effects, destroying 89% of cancer cells while barely affecting healthy cells, suggesting magnetic fields could improve chemotherapy treatments.
Why This Matters
This research demonstrates that static magnetic fields can amplify cancer treatment effectiveness by selectively targeting cancer cells through oxidative stress mechanisms. The magnetic field strengths tested (7-15 mT) are significantly higher than typical environmental exposures but within the range of some medical devices and industrial equipment. What makes this study particularly noteworthy is the selectivity - the magnetic fields enhanced damage to cancer cells while largely sparing normal cells, suggesting the biological effects depend heavily on cell type and health status. This adds to the growing body of evidence that EMF bioeffects are complex and context-dependent, challenging the oversimplified narrative that all EMF effects are uniformly harmful or beneficial.
Exposure Details
- Magnetic Field
- 7, 10, and 15 mG
- Exposure Duration
- 24 and 48 h
Exposure Context
This study used 7, 10, and 15 mG for magnetic fields:
- 350Kx above the Building Biology guideline of 0.2 mG
- 70Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In this study, we reported the effects of simultaneous application of static magnetic field (SMF) and cisplatin as an anticancer drug on the oxidative stress in human cervical cancer (HeLa) cell line and normal skin fibroblast cells (Hu02).
The cells were exposed to different SMF intensities (7, 10, and 15 mT) for 24 and 48 h. IC50 concent...
Based on the obtained results, the highest and lowest death rate, respectively, in HeLa and Hu02 cel...
This study suggests that conjugation of both physical and chemical treatments could increase the oxidative stress in HeLa cell line and among three optional intensities of SMF, the intensity of 10 mT led to the higher damage to cancer cells in lower doses of drug.
Show BibTeX
@article{s_2017_simultaneous_application_of_cisplatin_393,
author = {Kamalipooya S and Abdolmaleki P and Salemi Z and Javani Jouni F and Zafari J and Soleimani H.},
title = {Simultaneous application of cisplatin and static magnetic field enhances oxidative stress in HeLa cell line},
year = {2017},
doi = {10.1007/s11626-017-0148-z},
url = {https://link.springer.com/article/10.1007/s11626-017-0148-z},
}