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Influence of extremely low-frequency magnetic field on the activity of antioxidant enzymes during skin wound healing in rats

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Glinka M, Sieroń A, Birkner E, Cieślar G · 2013

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Exposing rats to a 40 Hz, 10 mT magnetic field during wound healing increased an antioxidant enzyme in serum and decreased a marker of lipid damage in liver tissue.

Plain English Summary

Summary written for general audiences

Researchers measured the activity of antioxidant enzymes and a lipid peroxidation marker in male rats exposed to an extremely low-frequency magnetic field during skin wound healing. Each animal had an experimental cut wound on its back. The 40 Hz, 10 mT exposure was associated with increased glutathione peroxidase activity in serum and decreased malone dialdehyde in liver tissue, which the researchers described as suggesting inhibition of phospholipid peroxidation and stabilization of cellular membranes.

Why This Matters

The study looked at liver tissue homogenates and blood serum as its biological samples. Malone dialdehyde was used as an indicator of lipid peroxidation rate. The researchers suggested that ELF-MF could be a useful supplement in the complex treatment of prolonged wound healing, due to what they described as activation of the endogenous enzymatic antioxidant system.

Exposure Details

Magnetic Field
10 mT
Source/Device
40 Hz

Exposure Context

This study used 10 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 10 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 50 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 40 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 40 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study was to evaluate the activity of the antioxidant enzymes mitochondrial and cytosolic superoxide dismutase (EC 1.15.1.1), glutathione peroxidase (POX, EC 1.11.1.9) and glutathione S-transferase (EC 3.1.2.7), as well as the concentration of malone dialdehyde (MDA), as an indicator of lipid peroxidation rate in the liver tissue homogenates and blood serum of male rats exposed to extremely low-frequency magnetic field (ELF-MF) in order to improve the healing process of an experimental cut wound on the back of each animal.

The exposure to ELF-MF with frequency 40 Hz and magnetic flux density 10 mT induced an increase in P...

Based on the results obtained, it seems that ELF-MF could be a useful supplement in the complex treatment of prolonged wound healing, due to the activation of endogenous enzymatic antioxidant system.

Cite This Study
Glinka M, Sieroń A, Birkner E, Cieślar G (2013). Influence of extremely low-frequency magnetic field on the activity of antioxidant enzymes during skin wound healing in rats Electromagn Biol Med. 32(4):463-470, 2013.
Show BibTeX
@article{m_2013_influence_of_extremely_lowfrequency_376,
  author = {Glinka M and Sieroń A and Birkner E and Cieślar G},
  title = {Influence of extremely low-frequency magnetic field on the activity of antioxidant enzymes during skin wound healing in rats},
  year = {2013},
  doi = {10.3109/15368378.2012.743906},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2012.743906},
}
DOI: 10.3109/15368378.2012.743906

Cited By (20 papers)

Quick Questions About This Study

The study used an extremely low-frequency magnetic field at 40 Hz and a magnetic flux density of 10 mT.
Researchers measured antioxidant enzyme activity, including glutathione peroxidase and superoxide dismutase, and the concentration of malone dialdehyde as an indicator of lipid peroxidation rate, in liver tissue and blood serum.
MDA contents in the liver tissue decreased after exposure, which the researchers suggested indicates inhibition of phospholipid peroxidation and stabilization of cellular membranes.
The researchers suggested that ELF-MF could be a useful supplement in the complex treatment of prolonged wound healing.
The study used male rats, each given an experimental cut wound on the back.