Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation.
Dutta SK, Das K, Ghosh B, Blackman CF · 1992
View Original AbstractRF radiation at 147-MHz altered brain enzyme activity in the same dose-dependent pattern that disrupts cellular calcium release.
Plain English Summary
Researchers exposed neuroblastoma brain cells to 147-MHz radio frequency radiation (similar to frequencies used in wireless devices) for 30 minutes and found it increased activity of acetylcholinesterase, a key enzyme involved in brain cell communication. The effect only occurred at specific power levels that had previously been shown to disrupt calcium release in the same type of cells. This suggests that RF radiation can interfere with fundamental brain cell processes that control neurotransmitter function.
Why This Matters
This 1992 study provides early evidence that radio frequency radiation can disrupt basic neurological processes at the cellular level. What makes this research particularly significant is that it demonstrates RF effects on acetylcholinesterase, an enzyme critical for proper brain function and neurotransmitter regulation. The researchers found that the same power densities that previously disrupted calcium ion release also altered this enzyme's activity, suggesting a consistent biological mechanism. The study used 147-MHz radiation, which falls within the range of frequencies used by many wireless communication devices today. While this was laboratory research on isolated cells rather than whole organisms, it adds to the growing body of evidence that RF radiation can affect nervous system function at levels below current safety standards. The dose-dependent 'window' effects observed here mirror findings in other EMF research, where biological effects occur at specific exposure levels rather than following a simple linear relationship.
Exposure Information
Specific exposure levels were not quantified in this study. The study examined exposure from: 147-MHz radiation, AM at 16 Hz Duration: 30 minutes
Study Details
we have examined the impact of RFR exposure on a membrane-bound enzyme, acetylcholinesterase (AChE), which is intimately involved with the acetylcholine (ACh) neurotransmitter system.
Neuroblastoma cells (NG108), exposed for 30 min to 147-MHz radiation, AM at 16 Hz, demonstrated enha...
Enhanced activity was observed within a time window between 7.0 and 7.5 h after the cells were plate...
Thus RFR affects both calcium-ion release and AChE activity in nervous system-derived cells in culture in a common dose-dependent manner.
Show BibTeX
@article{sk_1992_dose_dependence_of_acetylcholinesterase_2047,
author = {Dutta SK and Das K and Ghosh B and Blackman CF},
title = {Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation.},
year = {1992},
url = {https://pubmed.ncbi.nlm.nih.gov/1510740/},
}