Evaluation of oxidant stress and antioxidant defense in discrete brain regions of rats exposed to 900 MHz radiation.
Narayanan SN, Kumar RS, Kedage V, Nalini K, Nayak S, Bhat PG · 2014
View Original AbstractAdolescent rats exposed to 900 MHz RF-EMR for a month showed elevated oxidative stress markers across all brain regions studied, along with altered behavioral performance.
Plain English Summary
Researchers studied the effects of 900 MHz radio-frequency electromagnetic radiation on oxidant stress and antioxidant defense in discrete brain regions of adolescent rats. Thirty-six male Wistar rats aged 6 to 8 weeks were divided into a control group, a sham group, and an RF-EMR-exposed group, with 12 animals in each group. The exposed group received 900 MHz RF-EMR at a peak power density of 146.60 µW/cm2 for one hour per day for four weeks from an activated GSM mobile phone. Elevated TBARS levels were found in all brain regions studied, and altered behavioral performances were found in RF-EMR-exposed rats.
Why This Matters
TBARS, total antioxidants, and glutathione S-transferase activity were measured in the amygdala, hippocampus, frontal cortex, and cerebellum. RF-EMR exposure significantly decreased total antioxidants in the amygdala and cerebellum, but total antioxidant levels were not significantly changed in other brain regions. Glutathione S-transferase activity was significantly decreased in the hippocampus but was unaltered in the other brain regions studied. The researchers suggested that RF-EMR-induced oxidative stress could be one of the underlying causes for the behavioral deficits seen in rats after RF-EMR exposure.
Exposure Details
- Power Density
- 0.1466 mW/cm²
- Source/Device
- 900 MHz
- Exposure Duration
- 1 h/day for four weeks
Exposure Context
This study used 0.1466 mW/cm² for radio frequency:
- 14.7Mx above the Building Biology guideline of 0.1 μW/m²
- 244.3Kx above the BioInitiative Report recommendation of 0.0006 μW/cm²
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In the current study, the effects of 900 MHz radio-frequency electromagnetic radiation (RF-EMR) on levels of thiobarbituric acid-reactive substances (TBARS), total antioxidants (TA), and glutathione S-transferase (GST) activity in discrete brain regions were studied in adolescent rats.
Thirty-six male Wistar rats (6-8 weeks old) were allotted into three groups (n = 12 in each group). ...
Altered behavioral performances were found in RF-EMR-exposed rats. Additionally, elevated TBARS leve...
RF-EMR exposure for a month induced oxidative stress in rat brain, but its magnitude was different in different regions studied. RF-EMR-induced oxidative stress could be one of the underlying causes for the behavioral deficits seen in rats after RF-EMR exposure
Show BibTeX
@article{sn_2014_evaluation_of_oxidant_stress_151,
author = {Narayanan SN and Kumar RS and Kedage V and Nalini K and Nayak S and Bhat PG},
title = {Evaluation of oxidant stress and antioxidant defense in discrete brain regions of rats exposed to 900 MHz radiation.},
year = {2014},
url = {https://manipal.pure.elsevier.com/en/publications/evaluation-of-oxidant-stress-and-antioxidant-defense-in-discrete-},
}