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Oxidative Stress

Influence of environmental static electric field on antioxidant enzymes activities in hepatocytes of mice.

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Wu SX, Xu YQ, Di GQ, Jiang JH, Xin L, Wu TY · 2016

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Exposure to environmental static electric fields raised superoxide dismutase activity in mice, but other oxidative stress markers showed only minimal changes.

Plain English Summary

Summary written for general audiences

Researchers exposed male mice to environmental static electric fields for 35 days and measured antioxidant enzyme activity in liver homogenates. Superoxide dismutase activity increased significantly in both exposed groups on the 7th and 35th days, while glutathione S-transferase, glutathione peroxidase, and malonaldehyde showed only minimal changes. The researchers concluded that there was a weak relationship between exposure to environmental static electric fields and hepatic oxidative stress in living organisms.

Why This Matters

Three groups of mice were used: one exposed to field intensities of 9.2-21.85 kV/m, one to 2.3-15.4 kV/m, and a control group at 0 kV/m. Liver homogenates were collected on days 7, 14, 21, and 35 of the exposure cycle. The significant rise in superoxide dismutase activity appeared in both exposed groups, not just the higher-intensity group. Because most other oxidative stress markers changed only minimally, the study described the overall relationship between static electric field exposure and hepatic oxidative stress as weak.

Exposure Details

Electric Field
2300-15400 V/m
Exposure Duration
35 days

Exposure Context

This study used 2300-15400 V/m for electric fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Study Details

In this study, the effects of chronic exposure to environmental static electric fields on some antioxidant enzymes activities in the hepatocytes of mice were investigated.

Male Institute of Cancer Research mice were exposed for 35 days to environmental static electric fie...

The results revealed a significant increase in superoxide dismutase activity in both EG-I and EG-II ...

These results revealed a weak relationship between the exposure to environmental static electric fields and hepatic oxidative stress in living organisms.

Cite This Study
Wu SX, Xu YQ, Di GQ, Jiang JH, Xin L, Wu TY (2016). Influence of environmental static electric field on antioxidant enzymes activities in hepatocytes of mice. Genet Mol Res. Genet Mol Res. 15(3), 2016. doi: 10.4238/gmr.15038800.
Show BibTeX
@article{sx_2016_influence_of_environmental_static_480,
  author = {Wu SX and Xu YQ and Di GQ and Jiang JH and Xin L and Wu TY},
  title = {Influence of environmental static electric field on antioxidant enzymes activities in hepatocytes of mice.},
  year = {2016},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/27525865/},
}
PubMed: 27525865

Cited By (1 paper)

Quick Questions About This Study

The study used male Institute of Cancer Research mice, and enzyme activity was measured in liver homogenates.
One group was exposed to 9.2-21.85 kV/m, a second group to 2.3-15.4 kV/m, and a control group was kept at 0 kV/m.
Superoxide dismutase activity increased significantly in both exposed groups on days 7 and 35 of the exposure cycle.
Glutathione S-transferase, glutathione peroxidase, and malonaldehyde showed only minimal changes during the exposure cycle.
The results revealed a weak relationship between exposure to environmental static electric fields and hepatic oxidative stress in living organisms.