Selenium supplementation ameliorates static magnetic field-induced disorders in antioxidant status in rat tissues.
Ghodbane S, Amara S, Garrel C, Arnaud J, Ducros V, Favier A, Sakly M, Abdelmelek H. · 2011
View Original AbstractSelenium supplementation ameliorated antioxidant capacity in rat tissues exposed to a static magnetic field.
Plain English Summary
Researchers exposed male adult rats to a static magnetic field (128 mT, 1 hour per day for 5 days) and examined antioxidant enzymes and selenium levels in liver, kidney, muscle, and brain. Static magnetic field exposure decreased selenium levels in kidney, muscle, and brain, and decreased GPx activity in kidney and muscle. In the liver, static magnetic field exposure increased total GSH levels and total SOD activities, while glutathione reductase activity was unaffected. Selenium supplementation restored selenium levels and GPx activity in kidney and muscle, but did not bring down the elevated GSH and SOD levels in liver.
Why This Matters
The study divided male adult rats into four groups: untreated controls, SMF-exposed rats, selenium-treated rats given sodium selenite in drinking water for 4 weeks, and a co-exposed group receiving both treatments. The researchers described the magnetic field exposure as sub-acute and found that it altered the antioxidant response by decreasing total selenium in kidney, muscle, and brain. Selenium supplementation corrected some, but not all, of the changes associated with static magnetic field exposure, as liver GSH and SOD remained elevated.
Exposure Details
- Magnetic Field
- 128 mT
- Exposure Duration
- 1 h/day for 5 days
Exposure Context
This study used 128 mT for magnetic fields:
- 6.4Mx above the Building Biology guideline of 0.2 mG
- 1.3Mx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this study was to investigate the effect of selenium supplementation on the antioxidant enzymatic system (such as GPx, GR and SOD), GSH and selenium level in liver, kidney, muscle and brain of static magnetic field (SMF) exposed rats.
Male adult rats were divided into control rats (n = 6), SMF-exposed rats (128 mT; 1 h/day for 5 days...
Sub-acute exposure to SMF induces a decrease of selenium levels in kidney, muscle and brain. Our res...
Our investigations suggested that sub-acute exposure to SMF altered the antioxidant response by decreasing the level of total selenium in kidney, muscle and brain. Interestingly, selenium supplementation ameliorates antioxidant capacity in rat tissues exposed to SMF.
Show BibTeX
@article{s_2011_selenium_supplementation_ameliorates_static_371,
author = {Ghodbane S and Amara S and Garrel C and Arnaud J and Ducros V and Favier A and Sakly M and Abdelmelek H.},
title = {Selenium supplementation ameliorates static magnetic field-induced disorders in antioxidant status in rat tissues.},
year = {2011},
url = {https://www.sciencedirect.com/science/article/pii/S1382668910001523},
}