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Oxidative Stress

Protein oxidation under extremely low frequency electric field in guinea pigs. Effect of N-acetyl-L-cysteine treatment.

No Effects Found

Güler G, Türközer Z, Ozgur E, Tomruk A, Seyhan N, Karasu C · 2009

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High-intensity electric field exposure (12 kV/m) didn't cause protein damage in guinea pigs, suggesting everyday power line exposures pose minimal oxidative risk.

Plain English Summary

Summary written for general audiences

Researchers exposed guinea pigs to power line frequency electric fields (12 kV/m for 8 hours daily over 7 days) to study protein damage and whether the antioxidant N-acetyl-L-cysteine could protect against it. The study found no significant protein damage from the electric field exposure alone, though it did reduce a protein synthesis marker in the liver. The antioxidant treatment showed some effects on protein markers, suggesting it may have biological activity in this context.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

The study examined exposure from: 50 Hz Duration: 7 days/8 h/day

Study Details

In this study, we detected protein carbonyl content (PCO), advanced oxidation protein products (AOPP) in liver and 3-nitrotyrosine (3-NT) levels in plasma of guinea pigs in order to investigate the effects of N-acetyl-L-cysteine (NAC) administration on oxidative protein damage induced by power frequency electric (E) field (50 Hz, 12 kV/m, 7 days/8 h/day).

We also analyzed hepatic hydroxyproline level to study protein synthesis. According to the findings ...

However, liver hydroxyproline level was significantly diminished in the E field exposure group compa...

Cite This Study
Güler G, Türközer Z, Ozgur E, Tomruk A, Seyhan N, Karasu C (2009). Protein oxidation under extremely low frequency electric field in guinea pigs. Effect of N-acetyl-L-cysteine treatment. Gen Physiol Biophys. 28(1):47-55, 2009a.
Show BibTeX
@article{g_2009_protein_oxidation_under_extremely_2845,
  author = {Güler G and Türközer Z and Ozgur E and Tomruk A and Seyhan N and Karasu C},
  title = {Protein oxidation under extremely low frequency electric field in guinea pigs. Effect of N-acetyl-L-cysteine treatment.},
  year = {2009},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/19390136/},
}
PubMed: 19390136

Cited By (29 papers)

Quick Questions About This Study

A 2009 study found that 12 kV/m electric field exposure (50 Hz) for 8 hours daily over 7 days did not cause significant protein damage in guinea pigs. However, the exposure did reduce hydroxyproline levels in the liver, indicating some biological effects on protein synthesis markers.
Research on guinea pigs showed that N-acetyl-L-cysteine (NAC) treatment affected protein markers when combined with 12 kV/m electric field exposure. The antioxidant demonstrated biological activity in this context, though the electric field alone caused no significant protein oxidation damage.
Guinea pigs exposed to 12 kV/m electric fields for 7 days showed significantly reduced hydroxyproline levels in liver tissue compared to controls. This suggests the power line frequency exposure affected protein synthesis processes, even without causing oxidative protein damage.
A 2009 study used guinea pigs to examine protein oxidation from 12 kV/m electric field exposure over 7 days. The research found measurable changes in liver protein markers, suggesting guinea pigs can detect biological responses to power frequency electric fields.
Research showed that 8 hours daily of 12 kV/m electric field exposure for 7 days reduced liver hydroxyproline levels in guinea pigs. This indicates that protein synthesis markers can be affected within one week of power frequency electric field exposure.