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Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study.

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Koeman T, Schouten LJ, van den Brandt PA, Slottje P, Huss A, Peters S, Kromhout H, Vermeulen R. · 2015

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Occupational exposure to metals, chlorinated solvents, and ELF-MF showed positive associations with non-vascular dementia among men, driven by metals, while pesticide exposure showed inverse associations.

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Summary written for general audiences

Researchers analyzed occupational exposures to solvents, pesticides, metals, ELF-MF, electrical shocks, and diesel motor exhaust on non-vascular dementia mortality in the Netherlands Cohort Study. Exposures were assigned using job-exposure matrices and after 17.3 years of follow-up, 682 male and 870 female cases were available. Positive associations were found for metals, chlorinated solvents, and ELF-MF with non-vascular dementia among men, while pesticide exposure showed inverse associations and no associations were found for shocks, aromatic solvents, and diesel motor exhaust.

Why This Matters

The study aimed to observe occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study. Consistent positive associations were found between occupational exposure to metals and non-vascular dementia, though the pesticide finding is not supported in the overall literature.

Study Details

The aim of this study is to observe Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study.

We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low fre...

Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with n...

Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature.

Cite This Study
Koeman T, Schouten LJ, van den Brandt PA, Slottje P, Huss A, Peters S, Kromhout H, Vermeulen R. (2015). Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study. Am J Ind Med. 58(6):625-635, 2015.
Show BibTeX
@article{t_2015_occupational_exposures_and_risk_1752,
  author = {Koeman T and Schouten LJ and van den Brandt PA and Slottje P and Huss A and Peters S and Kromhout H and Vermeulen R.},
  title = {Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study.},
  year = {2015},
  doi = {10.1002/ajim.22462},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ajim.22462},
}
DOI: 10.1002/ajim.22462

Cited By (23 papers)

Quick Questions About This Study

The study analyzed exposures to solvents, pesticides, metals, ELF-MF, electrical shocks, and diesel motor exhaust.
Occupational exposure to metals, chlorinated solvents, and ELF-MF showed positive associations with non-vascular dementia among men, driven by metals.
Pesticide exposure showed statistically significant inverse associations with non-vascular dementia among men.
No associations were found for shocks, aromatic solvents, and diesel motor exhaust.
Exposures were assigned using job-exposure matrices and after 17.3 years of follow-up, 682 male and 870 female cases were available.