Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes
Zhao TY, Zou SP, Knapp PE. · 2007
View Original AbstractPrimary neurons and astrocytes exposed to GSM cell phone radiation at 1900 MHz for 2 hours showed up-regulation of apoptosis-related genes.
Plain English Summary
Researchers exposed primary cultured neurons and astrocytes to GSM cell phone emissions at 1900 MHz for 2 hours. Neurons showed up-regulation of caspase-2, caspase-6, and Asc genes in both 'on' and 'stand-by' modes. Astrocytes showed up-regulation of the same genes only in 'on' mode and also up-regulated the Bax gene.
Why This Matters
The researchers concluded that even short-term exposure can up-regulate apoptotic pathway elements in brain-derived cells, with neurons appearing more sensitive than astrocytes. The up-regulation was specific, as caspase-9 and Bax in neurons did not show increased expression.
Exposure Information
Specific exposure levels were not quantified in this study. The study examined exposure from: 1900 MHz Duration: 2 h
Study Details
This study investigated whether expression of genes related to cell death pathways are dysregulated in primary cultured neurons and astrocytes by exposure to a working Global System for Mobile Communication (GSM) cell phone rated at a frequency of 1900 MHz.
Primary cultures were exposed to cell phone emissions for 2 h. We used array analysis and real-time ...
Up-regulation occurred in both “on” and “stand-by” modes in neurons, but only in “on” mode in astroc...
The results show that even relatively short-term exposure to cell phone radiofrequency emissions can up-regulate elements of apoptotic pathways in cells derived from the brain, and that neurons appear to be more sensitive to this effect than astrocytes.
Show BibTeX
@article{ty_2007_exposure_to_cell_phone_1551,
author = {Zhao TY and Zou SP and Knapp PE.},
title = {Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes},
year = {2007},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0304394006010056},
}