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Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.

No apoptosis is induced in rat cortical neurons exposed to GSM phone fields.

No Effects Found

Joubert V, Leveque P, Cueille M, Bourthoumieu S, Yardin C. · 2007

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Rat cortical neurons exposed to GSM fields for 24 hours showed no significant increase in apoptosis.

Plain English Summary

Summary written for general audiences

Researchers exposed primary cultured neurons from embryonic Wistar rat cortices to a 900-MHz GSM field for 24 hours at 0.25 W/kg SAR. Apoptosis was measured immediately and 24 hours after exposure using DAPI staining, TUNEL/PI flow cytometry, and caspase-3 fluorimetry. No statistically significant difference in apoptosis rate was found between exposed and control neurons at either time point. All three assessment methods gave concordant results.

Why This Matters

The study aimed to investigate RF EMF effects on neuronal apoptosis in vitro. The authors noted this was the first such study on cultured cortical neurons and aligned with prior cell line studies.

Exposure Details

SAR
0.25 W/kg
Source/Device
900‐MHz
Exposure Duration
24 h

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.25 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 6 times higher than this level

Study Details

The aim of this study was to investigate the radiofrequency (RF) electromagnetic fields (EMF) effects on neuronal apoptosis in vitro.

Primary cultured neurons from cortices of embryonic Wistar rats were exposed to a 900‐MHz global sys...

No statistically significant difference in the apoptosis rate was observed between controls and 24 h...

Cite This Study
Joubert V, Leveque P, Cueille M, Bourthoumieu S, Yardin C. (2007). No apoptosis is induced in rat cortical neurons exposed to GSM phone fields. Bioelectromagnetics. 28(2):115-121, 2007.
Show BibTeX
@article{v_2007_no_apoptosis_is_induced_2766,
  author = {Joubert V and Leveque P and Cueille M and Bourthoumieu S and Yardin C. },
  title = {No apoptosis is induced in rat cortical neurons exposed to GSM phone fields.},
  year = {2007},
  doi = {10.1002/bem.20274},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20274},
}

Cited By (83 papers)

Quick Questions About This Study

Primary cultured neurons from embryonic Wistar rat cortices were studied.
Neurons were exposed to a 900-MHz GSM field for 24 hours.
The average specific absorption rate was 0.25 W/kg.
Apoptosis was assessed using DAPI staining, TUNEL/PI flow cytometry, and caspase-3 fluorimetry immediately and 24 hours after exposure.
No statistically significant difference in apoptosis rate was observed between exposed and control neurons at either time point.