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Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats

Bioeffects Seen

Ghazizadeh V, Nazıroğlu M · 2014

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Exposure Details

SAR
0.00052 W/kg
Power Density
0.012 mW/cm²
Source/Device
2.45 GHz
Exposure Duration
continuous for 1 hour

Exposure Context

This study used 0.012 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.012 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)FCC limit is 83 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

Incidence rates of epilepsy and use of Wi-Fi worldwide have been increasing. TRPV1 is a Ca(2+) permeable and non-selective channel, gated by noxious heat, oxidative stress and capsaicin (CAP). The hyperthermia and oxidant effects of Wi-Fi may induce apoptosis and Ca(2+) entry through activation of TRPV1 channel in epilepsy. Therefore, we tested the effects of Wi-Fi (2.45 GHz) exposure on Ca(2+) influx, oxidative stress and apoptosis through TRPV1 channel in the murine dorsal root ganglion (DRG) and hippocampus of pentylentetrazol (PTZ)-induced epileptic rats.

Rats in the present study were divided into two groups as controls and PTZ. The PTZ groups were divi...

The cytosolic free Ca(2+), reactive oxygen species production, apoptosis, mitochondrial membrane dep...

In conclusion, epilepsy and Wi-Fi in our experimental model is involved in Ca(2+) influx and oxidative stress-induced hippocampal and DRG death through activation of TRPV1 channels, and negative modulation of this channel activity by CPZ pretreatment may account for the neuroprotective activity against oxidative stress.

Cite This Study
Ghazizadeh V, Nazıroğlu M (2014). Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats Metab Brain Dis. 29(3):787–799,(2014).
Show BibTeX
@article{v_2014_electromagnetic_radiation_wifi_and_102,
  author = {Ghazizadeh V and Nazıroğlu M},
  title = {Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats},
  year = {2014},
  doi = {10.1007/s11011-014-9549-9},
  url = {https://link.springer.com/article/10.1007/s11011-014-9549-9},
}
DOI: 10.1007/s11011-014-9549-9

Cited By (63 papers)

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