Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.
Nazıroğlu M, Çelik Ö, Özgül C, Çiğ B, Doğan S, Bal R, Gümral N, Rodríguez AB, Pariente JA. · 2012
View Original AbstractMelatonin supplementation seemed to have protective effects against 2.45 GHz electromagnetic radiation-induced increases in calcium influx, EEG spike activity, and cell viability changes in rat brain and dorsal root ganglion neurons.
Plain English Summary
Researchers divided rats into four groups: a cage control, a sham control, a group exposed to 2.45 GHz electromagnetic radiation, and a group exposed to the same radiation while also receiving melatonin. The radiation-exposed groups received that exposure for 60 minutes per day for 30 days, after which brain cortex and dorsal root ganglion samples and EEG recordings were collected. Lipid peroxidation, cell viability, and cytosolic calcium values in dorsal root ganglion neurons were higher in the radiation-only group than in the control groups. The melatonin-plus-radiation group showed lower EEG spike numbers and higher brain cortex vitamin E concentration compared with the radiation-only group.
Why This Matters
The study aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation on brain and dorsal root ganglion neuron antioxidant redox system, calcium influx, cell viability, and EEG records in the rat. Certain agents, including 2-aminoethyldiphenyl borinate, diltiazem, and verapamil, also affected lipid peroxidation, cell viability, and calcium concentrations alongside melatonin. The researchers concluded that melatonin's protective effects appeared to work through TRPM2 channels and voltage-gated calcium channels.
Exposure Details
- SAR
- 0.143, 0.1 W/kg
- Power Density
- 0.0001 mW/cm²
- Electric Field
- 11 V/m
- Source/Device
- 2.45 GHz
- Exposure Duration
- 1 h/day on 30 days
Exposure Context
This study used 0.0001 mW/cm² for radio frequency:
- 10Kx above the Building Biology guideline of 0.1 μW/m²
- 166.7x above the BioInitiative Report recommendation of 0.0006 μW/cm²
This study used 11 V/m for electric fields:
- 36.7x above the Building Biology guideline of 0.3 V/m
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca2+ influx, cell viability and electroencephalography (EEG) records in the rat.
Thirty two rats were equally divided into four different groups namely group A1: Cage control, group...
Lipid peroxidation (LP), cell viability and cytosolic Ca2+ values in DRG neurons were higher in grou...
In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca2+ influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca2+ channels.
Show BibTeX
@article{m_2012_melatonin_modulates_wireless_245_154,
author = {Nazıroğlu M and Çelik Ö and Özgül C and Çiğ B and Doğan S and Bal R and Gümral N and Rodríguez AB and Pariente JA.},
title = {Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.},
year = {2012},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0031938411004823},
}