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DNA & Genetic Damage

Frequency of micronuclei in the peripheral blood and bone marrow of cancer-prone mice chronically exposed to 2450 MHz radiofrequency radiation.

No Effects Found

Vijayalaxmi, Frei, MR, Dusch, SJ, Guel, V, Meltz, ML, Jauchem, JR · 1997

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Eighteen months of microwave radiation exposure at cell phone-level intensities caused no detectable DNA damage in cancer-prone mice.

Plain English Summary

Summary written for general audiences

Researchers exposed cancer-prone mice to 2450 MHz radiofrequency radiation (the same frequency used in microwave ovens and some WiFi) for 20 hours daily over 18 months to test whether it causes DNA damage. They measured micronuclei - tiny fragments that indicate genetic damage - in blood and bone marrow cells. The study found no significant difference in DNA damage between exposed and unexposed mice, suggesting this level of RF exposure did not cause detectable genetic harm.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 2450 MHz Duration: 20 h/day, 7 days/week, over 18 months to continuous-wave

Study Details

The aim of this study is to investigate Frequency of micronuclei in the peripheral blood and bone marrow of cancer-prone mice chronically exposed to 2450 MHz radiofrequency radiation.

C3H/HeJ mice, which are prone to mammary tumors, were exposed for 20 h/day, 7 days/week, over 18 mon...

The results indicate that the incidence of micronuclei/1,000 PCEs was not significantly different be...

Thus there was no evidence for genotoxicity in mice prone to mammary tumors that were exposed chronically to 2450 MHz RF radiation compared with sham-exposed controls.

Cite This Study
Vijayalaxmi, Frei, MR, Dusch, SJ, Guel, V, Meltz, ML, Jauchem, JR (1997). Frequency of micronuclei in the peripheral blood and bone marrow of cancer-prone mice chronically exposed to 2450 MHz radiofrequency radiation. Radiat Res 147(4):495-500, 1997.
Show BibTeX
@article{vijayalaxmi_1997_frequency_of_micronuclei_in_3467,
  author = {Vijayalaxmi and Frei and MR and Dusch and SJ and Guel and V and Meltz and ML and Jauchem and JR},
  title = {Frequency of micronuclei in the peripheral blood and bone marrow of cancer-prone mice chronically exposed to 2450 MHz radiofrequency radiation.},
  year = {1997},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/9092931/},
}
PubMed: 9092931

Cited By (83 papers)

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Quick Questions About This Study

No, a 1997 study found no genetic damage in cancer-prone mice exposed to 2450 MHz radiation for 20 hours daily over 18 months. Micronuclei levels (indicators of DNA damage) remained similar between exposed and control groups in both blood and bone marrow cells.
Research shows 2450 MHz radiation does not damage bone marrow cells even with chronic exposure. Mice exposed for 18 months showed micronuclei frequencies of 6.1 compared to 5.7 in unexposed controls - a statistically insignificant difference indicating no genetic harm.
No, 18 months of exposure to 2450 MHz radiation (microwave oven frequency) was not genotoxic to blood cells. Exposed mice showed 4.5 micronuclei per 1,000 cells versus 4.0 in controls, demonstrating no significant increase in DNA damage markers.
No, tumor-bearing mice showed no increased DNA damage from 2450 MHz exposure. Blood micronuclei levels were 4.6 in exposed tumor mice versus 4.1 in unexposed tumor mice, while bone marrow levels were 6.1 versus 5.5 - both statistically insignificant differences.
Micronuclei testing found no evidence that chronic 2450 MHz radiation (used in WiFi) causes genetic damage. After 18 months of exposure, both blood and bone marrow cells showed normal DNA damage levels, suggesting this frequency doesn't increase genotoxic risk.