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[A aquaporin 4 expression and effects in rat hippocampus after microwave radiation.]

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Li X, Hu XJ, Peng RY, Gao YB, Wang SM, Wang LF, Xu XP, Su ZT, Yang GS. · 2009

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Microwave radiation increased AQP4 expression in rat hippocampus, with protein levels recovering at 10 and 30 mW/cm(2) but rising progressively at 100 mW/cm(2).

Plain English Summary

Summary written for general audiences

Researchers exposed 70 male rats to microwave radiation at average power densities of 0, 10, 30, and 100 mW/cm(2). Rats were sacrificed at 6 hours, 1 day, 3 days, and 7 days after exposure. Protein levels of AQP4 increased initially and then recovered at 10 and 30 mW/cm(2), but increased progressively at 100 mW/cm(2) within 14 days. Gene expression of AQP4 increased at 6 hours after 10 mW/cm(2) exposure and returned to baseline, while at 30 and 100 mW/cm(2) it peaked at 7 days and did not return.

Why This Matters

The authors reported that AQP4 expression in the hippocampus was abnormal after exposure to 10, 30, and 100 mW/cm(2) microwave radiation. They concluded that microwave radiation can increase AQP4 expression in rat hippocampus. They suggested that the increase in AQP4 might contribute to increased blood-brain barrier permeability and brain edema.

Exposure Details

Power Density
0, 10, 30 and 100 mW/cm²

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextExtreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²

Study Details

To investigate the expression of aquaporin 4 (AQP4) after microwave exposure and the correlation with the brain injury by radiation.

70 male rats were exposed to microwave whose average power density was 0, 10, 30 and 100 mW/cm(2) re...

The expression of AQP4 in rat hippocampus was abnormal after 10, 30, 100 mW/cm(2) microwave exposure...

Microwave radiation can increase the expression of AQP4 in rat hippocampus. The change might participate in the process of increasing permeability of blood-brain barrier and lead to the brain edema after microwave radiation.

Cite This Study
Li X, Hu XJ, Peng RY, Gao YB, Wang SM, Wang LF, Xu XP, Su ZT, Yang GS. (2009). [A aquaporin 4 expression and effects in rat hippocampus after microwave radiation.] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 27(9):534-538, 2009.
Show BibTeX
@article{x_2009_a_aquaporin_4_expression_1152,
  author = {Li X and Hu XJ and Peng RY and Gao YB and Wang SM and Wang LF and Xu XP and Su ZT and Yang GS.},
  title = {[A aquaporin 4 expression and effects in rat hippocampus after microwave radiation.]},
  year = {2009},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/20137298/},
}
PubMed: 20137298

Quick Questions About This Study

Protein levels of AQP4 increased initially and then recovered at 10 and 30 mW/cm(2), but increased progressively at 100 mW/cm(2) within 14 days.
Gene expression of AQP4 increased at 6 hours after 10 mW/cm(2) exposure and returned to baseline, while at 30 and 100 mW/cm(2) it peaked at 7 days and did not return.
The authors suggested that increased AQP4 expression might participate in increased blood-brain barrier permeability and lead to brain edema after microwave radiation.
Immunohistochemistry and Western blot were used for protein level, and in situ hybridization and RT-PCR for gene level.