Effects of aluminum and extremely low frequency electromagnetic radiation on oxidative stress and memory in brain of mice.
Deng Y, Zhang Y, Jia S, Liu J, Liu Y, Xu W, Liu L. · 2013
View Original AbstractBoth aluminum and extremely low-frequency magnetic fields were associated with learning memory impairment and oxidative stress changes in mice, but combining them caused no more damage than either alone.
Plain English Summary
Researchers divided sixty male SPF Kunming mice into four groups: a control group, an ELF-MF group exposed at 2 mT for 4 hours per day, a group given aluminum at 200 mg per kg, and a combined ELF-MF plus aluminum group. After 8 weeks of treatment, all three exposure groups showed learning memory impairment, with prolonged escaping latency to the platform and a reduced percentage of time in the platform quadrant in the Morris water maze task. All three exposed groups showed a statistically significant decrease in superoxide dismutase activity and an increase in malondialdehyde levels. The combined ELF-MF plus aluminum treatment induced no more damage than ELF-MF and aluminum did separately.
Why This Matters
The study examined oxidative stress markers and memory in mice exposed to extremely low-frequency magnetic fields, aluminum, or both, over 8 weeks. Pathologic changes were also observed, including neuronal cell loss and overexpression of phosphorylated tau protein in the hippocampus and cerebral cortex of exposed mice. The markers of oxidative stress were determined in mice brain and serum across the exposed groups. The researchers found no evidence that combining ELF-MF with aluminum produced a greater effect than either exposure on its own.
Exposure Details
- Magnetic Field
- 2 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 4 h daily, 6 days per week for 8 weeks
Exposure Context
This study used 2 mT for magnetic fields:
- 100Kx above the Building Biology guideline of 0.2 mG
- 20Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
This study was aimed to investigate the effect of aluminum and extremely low-frequency magnetic fields (ELF-MF) on oxidative stress and memory of SPF Kunming mice.
Sixty male SPF Kunming mice were divided randomly into four groups: control group, ELF-MF group (2 m...
After 8 weeks of treatment, the mice of three experiment groups (ELF-MF group, load aluminum group, ...
In conclusion, both aluminum and ELF-MF could impact on learning memory and pro-oxidative function in Kunming mice. However, there was no evidence of any association between ELF-MF exposure with aluminum loading.
Show BibTeX
@article{y_2013_effects_of_aluminum_and_241,
author = {Deng Y and Zhang Y and Jia S and Liu J and Liu Y and Xu W and Liu L. },
title = {Effects of aluminum and extremely low frequency electromagnetic radiation on oxidative stress and memory in brain of mice.},
year = {2013},
url = {https://link.springer.com/article/10.1007%252Fs12011-013-9847-9},
}