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2.1 GHz electromagnetic field does not change contractility and intracellular Ca2+ transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes.

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Olgar Y, Hidisoglu E, Celen MC, Yamasan BE, Yargicoglu P, Ozdemir S. · 2015

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Long-term exposure to 2.1 GHz EMF reduced β-adrenergic responsiveness of rat ventricular myocytes through increased nitric oxide, while contractility and Ca2+ transients were unchanged.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to 2.1 GHz EMF for 2 hours per day over 10 weeks and compared them with sham-exposed rats. They measured sarcomere shortening, Ca2+ transients, and L-type Ca2+ currents in isolated ventricular myocytes. Exposure did not alter fractional shortening or Ca2+ transient amplitude, but reduced the isoproterenol-induced L-type Ca2+ current response while basal current density remained similar. Nitric oxide levels in heart tissue were significantly increased after EMF exposure.

Why This Matters

The study aimed to investigate how 2.1 GHz EMF affects contractility and β-adrenergic responsiveness of ventricular myocytes. The authors concluded that long-term EMF exposure decreases β-adrenergic responsiveness through nitric oxide signaling.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.10 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.10 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2.1 GHz Duration: 2 h/day for 10 weeks

Study Details

In this study we investigated the effect of 2.1 GHz EMF on contractility and beta-adrenergic (β-AR) responsiveness of ventricular myocytes.

Rats were randomized to the following groups: Sham rats (SHAM) and rats exposed to 2.1 GHz EMF for 2...

Fractional shortening and amplitude of the matched Ca2+ transients were not changed in EM-10 rats. A...

Long-term exposure to 2.1 GHz EMF decreases β-AR responsiveness of ventricular myocytes through NO signaling.

Cite This Study
Olgar Y, Hidisoglu E, Celen MC, Yamasan BE, Yargicoglu P, Ozdemir S. (2015). 2.1 GHz electromagnetic field does not change contractility and intracellular Ca2+ transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes. Int J Radiat Biol. 2015 Jul 1:1-23.
Show BibTeX
@article{y_2015_21_ghz_electromagnetic_field_1684,
  author = {Olgar Y and Hidisoglu E and Celen MC and Yamasan BE and Yargicoglu P and Ozdemir S.},
  title = {2.1 GHz electromagnetic field does not change contractility and intracellular Ca2+ transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes.},
  year = {2015},
  doi = {10.3109/09553002.2015.1068462},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2015.1068462},
}
DOI: 10.3109/09553002.2015.1068462

Cited By (5 papers)

Quick Questions About This Study

Rats were exposed to 2.1 GHz EMF for 2 hours per day for 10 weeks.
Fractional shortening and Ca2+ transient amplitude were not changed in EM-10 rats.
The isoproterenol-induced L-type Ca2+ current response was reduced, while basal current density was unchanged.
Nitric oxide levels in rat heart tissue increased significantly after EMF exposure.