Effects of single and repeated exposure to a 50-Hz 2-mT electromagnetic field on primary cultured hippocampal neurons
Zeng Y, Shen Y, Hong L, Chen Y, Shi X, Zeng Q, Yu P · 2017
View Original AbstractRepeated exposure to a 50-Hz 2-mT electromagnetic field decreased viability and increased reactive oxygen species in cultured hippocampal neurons, but had no significant effects on DNA damage, apoptosis, or autophagy.
Plain English Summary
Researchers evaluated the biological effects of different patterns of extremely low frequency magnetic field exposure on primary cultured hippocampal neurons, looking at viability, apoptosis, genomic instability, and oxidative stress. Repeated exposure to a 50-Hz 2-mT field for 8 hours per day decreased cell viability and increased the production of intracellular reactive oxygen species. The researchers noted that none of the repeated exposure patterns had significant effects on DNA damage, apoptosis, or autophagy, suggesting no severe biological consequences in the cultured neurons.
Why This Matters
The study evaluated different patterns of 50-Hz 2-mT magnetic field exposure on primary cultured hippocampal neurons. Repeated exposure was associated with lower cell viability and higher levels of intracellular reactive oxygen species. The researchers suggested the oxidative stress effect may be related to the up-regulation of Nox2 expression. Despite the oxidative stress findings, repeated exposure did not produce significant effects on DNA damage, apoptosis, or autophagy, which the researchers described as suggesting no severe biological consequences.
Exposure Details
- Magnetic Field
- 2 mT
- Source/Device
- 50-Hz
Exposure Context
This study used 2 mT for magnetic fields:
- 100Kx above the Building Biology guideline of 0.2 mG
- 20Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We evaluated the biological effects of different patterns of ELF-MF exposure on primary cultured hippocampal neurons in terms of viability, apoptosis, genomic instability, and oxidative stress.
The results showed that repeated exposure to 50-Hz 2-mT ELF-MF for 8 h per day after different times...
Show BibTeX
@article{y_2017_effects_of_single_and_488,
author = {Zeng Y and Shen Y and Hong L and Chen Y and Shi X and Zeng Q and Yu P},
title = {Effects of single and repeated exposure to a 50-Hz 2-mT electromagnetic field on primary cultured hippocampal neurons},
year = {2017},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567517/},
}