The mechanism of magnetic field-induced increase of excitability in hippocampal neurons.
Ahmed Z, Wieraszko A. · 2008
View Original AbstractA pulsed magnetic field applied to hippocampal tissue increased the excitability of neurons in a way that was independent of NMDA receptors.
Plain English Summary
Researchers investigated the influence of a pulsed magnetic field on hippocampal evoked potentials in vitro. Exposure to a pulsed magnetic field at 0.16 Hz and 15 mT, applied for 30 minutes, amplified the population spike and the slope of EPSP recorded from hippocampal tissue. The amplification was additive to previously induced long-term potentiation and occurred in an NMDA-independent way. The pulsed magnetic field also modified paired-pulse facilitation and paired-pulse inhibition, suggesting it affects both excitatory and inhibitory processes in the hippocampus.
Why This Matters
The study was conducted in vitro, meaning hippocampal tissue was studied outside a living animal. Researchers found that activity of electrical synapses increased alongside the pulsed magnetic field-induced amplification of evoked potentials. Control experiments were performed, and the researchers concluded that the observed effects were exclusively related to pulsed magnetic field exposure. The authors noted that their results support and extend previous research indicating a significant influence of magnetic fields on hippocampal physiology.
Exposure Details
- Magnetic Field
- 15 mT
- Source/Device
- 0.16 Hz
- Exposure Duration
- 30 min
Exposure Context
This study used 15 mT for magnetic fields:
- 750Kx above the Building Biology guideline of 0.2 mG
- 150Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The influence of a pulsed magnetic field (PMF) on hippocampal evoked potentials has been investigated in vitro.
The exposure to PMF (0.16 Hz, 15 mT) applied for 30 min amplified the population spike and the slope...
The increase in the activity of electrical synapses accompanied PMF-induced amplification of evoked ...
The results support and extend our previous research indicating a significant influence of magnetic fields on hippocampal physiology.
Show BibTeX
@article{z_2008_the_mechanism_of_magnetic_214,
author = {Ahmed Z and Wieraszko A.},
title = {The mechanism of magnetic field-induced increase of excitability in hippocampal neurons.},
year = {2008},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0006899308011566},
}